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Compound Overview
4-Chloro-2'-bromoacetophenone (CAS 536-38-9) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 536-38-9 |
|---|---|
| Molecular Formula | C8H6BrClO |
| Molecular Weight | 233.49 g/mol |
| SMILES | ClC1=CC=C(C=C1)C(=O)CBr |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).
Target(s): GSK-3
Signaling pathway(s): PI3K/Akt/mTOR signaling, Stem Cells
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Use a bath-type ultrasonic cleaner rather than a high-intensity ultrasonic disruptor. Bath sonicators provide gentle, uniform agitation appropriate for dissolving solid compounds without generating cavitation damage or excessive heat. Ensure the solvent tube is fully submerged and use short sonication pulses of 5–10 seconds.
For normal mice, the concentration of DMSO should be kept below 10%. For nude mice, transgenic mice, or mice with weak tolerance, the concentration of DMSO should be kept below 2%. For inhibitors being used for the first time, it is recommended to perform a solvent-negative control experiment to confirm that the solvent has no nonspecific effects on the animals.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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