| Field | Specification |
|---|---|
| Activity | |
| Cas No. | |
| Product Type | |
| Signaling Pathway | |
| Target |
Compound Overview
5α-Androstan-3β-ol (CAS 1224-92-6) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 1224-92-6 |
|---|---|
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
5alpha-Androstan-3beta-ol, a steroidal androgen, demonstrates selective interaction with cellular components, showing affinity for the androgen receptor (AR) with an IC50 of 1.7 uM and activating the pregnane X receptor (PXR) in HepG2 cells with an EC50 of 0.8 uM. It selectively inhibits the hydroxylase activities of 16alpha- and 6beta-hydroxylase over 16beta- or 7alpha-hydroxylase, with IC50 values of 70 and 110 uM, compared to >150 uM for the latter enzymes, indicating a specificity in its enzyme inhibition profile. Additionally, administration of this compound at a dosage of 30 mg/kg results in a decrease in testis weight and sperm production in mice, highlighting its biological effects on male reproductive parameters.
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Use a bath-type ultrasonic cleaner at standard cleaning frequency (37–40 kHz). Bath sonication is gentler than a probe sonicator and avoids sample overheating. Sonicate in 5–10 second intervals, checking solubility between pulses, for no more than 2–3 minutes total. Warm the bath to 37 °C if solubility remains poor.
Solubility data for each compound is provided on the TargetMol product page and DataSheet, listed as maximum solubility in DMSO and/or aqueous media (mg/mL and mM). For compounds not yet characterized, prepare a test dissolution at the intended stock concentration and visually confirm clarity before use. When preparing aqueous working solutions, always dilute from a DMSO stock and monitor for precipitation at your final assay concentration.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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