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Compound Overview
5α-Pregnane-3α,20α-diol (CAS 566-58-5) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 566-58-5 |
|---|---|
| Molecular Formula | C21H36O2 |
| Molecular Weight | 320.51 g/mol |
| SMILES | C(C)12(C)3((H))(C)(CC(C)1((H))C(CH)(CC2)O)((H))(C)4((H))(C)(CC3)((C)((… |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
5alpha-Pregnane-3alpha,20alpha-diol, an active metabolite of progesterone, is synthesized through intermediates 5alpha-pregnane-20alpha-ol-3-one and 5alpha-pregnane-3alpha-ol-20-one from progesterone. This compound, at a concentration of 10 uM, elevates intracellular calcium levels in washed isolated human platelets.
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Yes — TargetMol inhibitors can be used in cell-based and in vitro experiments. Prepare a DMSO stock, then dilute into cell culture medium to the desired working concentration, keeping DMSO ≤ 0.1% (v/v) to avoid solvent toxicity. Note that not all compounds have published data for every cell line or assay system; in such cases, perform a dose-response experiment with appropriate positive and vehicle controls to validate efficacy in your specific model.
sonication can accelerate dissolution. If the compound is not dissolving, sonication is recommended. If you don't have an ultrasound machine, a lower solvent concentration or using less powder are recommended.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
