| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | A-769662 |
| Cas No. | |
| Form | Off-white solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 100 mM in DMSO and to 10 mM in ethanol |
| Source | Synthetic |
| Storage |
A 769662 is a potent and reversible activator of AMP-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis. In neurodegenerative disease research, A 769662 is used to explore the role of AMPK in neuronal metabolism, autophagy, and stress resistance. Activation of AMPK by A 769662 has been shown to inhibit fatty acid synthesis and reduce plasma glucose and triglyceride levels, making it a promising compound for studying metabolic dysfunction in Alzheimer’s and Parkinson’s disease.
Classification: Not a hazardous substance or mixture.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
A 769662 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-490)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Göransson O., et al. (2007) J. Biol. Chem. 282(45): 32549–32560.
