| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
ABBV-712 (CAS 2368945-27-9) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 2368945-27-9 |
|---|---|
| Molecular Formula | C24H28N4O5 |
| Molecular Weight | 452.50 g/mol |
| SMILES | N(C(C)=O)C=1C=C2C(=CN(C2=CN1)C3COC3)C=4N=C(C=C(COC)C4)(C)5(OC)CCOC5 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 uM, and is implicated in the regulation of autoimmune diseases (1).
Target(s): JAK
Signaling pathway(s): Stem Cells, Chromatin/Epigenetic, JAK/STAT signaling, Angiogenesis
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Use a bath-type ultrasonic cleaner at standard cleaning frequency (37–40 kHz). Bath sonication is gentler than a probe sonicator and avoids sample overheating. Sonicate in 5–10 second intervals, checking solubility between pulses, for no more than 2–3 minutes total. Warm the bath to 37 °C if solubility remains poor.
If you are using DMSO for preparation,sterilization is not recommended, as DMSO itself possesses strong sterilizing properties. The prepared solution is sterile. For further assurance, it can be left overnight at 4°C. The safest method is to filter through a specialized organic filter membrane. If water is used for preparation,sterilization can be achieved by filtering through a 0.22 μm filter membrane.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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