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Compound Overview
ADAMTS-5-IN-3 (CAS 2688733-96-0) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 2688733-96-0 |
|---|---|
| Molecular Formula | C20H23Cl2N3O3 |
| Molecular Weight | 424.32 g/mol |
| SMILES | C(CC(=O)N1C(CH)(C)C=2C(CC1)=CC(Cl)=C(Cl)C2)(C)3(C(=O)NC(=O)N3)(CH)4CC4 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of ADAMTS-5 (IC50: 8 nM) and ADAMTS-4 (IC50: 12 nM).ADAMTS-5-IN-3 can be used to study diseases associated with cartilage degeneration or disruption of cartilage homeostasis, particularly osteoarthrosis and/or rheumatoid arthritis.
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Most small molecule inhibitors are not compatible with autoclaving (121 °C), which can cause thermal decomposition or loss of biological activity. For sterile cell-based experiments, filter-sterilize working solutions through a 0.2 µm membrane after dilution into aqueous buffer. Verify thermal stability in the DataSheet before applying any heat treatment.
mg/mL (milligrams per milliliter) and mM (millimolar = millimoles per liter) are two concentration units for the same solution. To convert: mM = (mg/mL × 1000) / MW (g/mol). For example, for a compound with MW = 350 g/mol: 1 mg/mL = 1000/350 = 2.86 mM. Use the molar concentration calculator on the TargetMol website for quick conversions.
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