| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | Tyrphostin AG 490, N-Benzyl-3,4-dihydroxybenzylidenecyanoacetamide, 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide, 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide |
| Cas No. | |
| Form | Tan solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (30 mg/ml), dimethyl formamide (40 mg/ml) or 100% ethanol (10 mg/ml) |
| Source | Synthetic |
| Storage |
AG490 is a selective inhibitor of JAK2/3 and EGF receptor tyrosine kinase. It also inhibits the downstream activation of STAT5a/b. AG490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.
Classification: Acute toxicity, Oral (Category 3), H301
Acute aquatic toxicity (Category 1), H400
Chronic aquatic toxicity (Category 1), H410
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
- H301 Toxic if swallowed.
- H410 Very toxic to aquatic life with long lasting effects.
Precautionary statements:
- P264 Wash skin thoroughly after handling.
- P270 Do not eat, drink or smoke when using this product.
- P273 Avoid release to the environment.
- P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/
- physician.
- P321 Specific treatment (see supplemental first aid instructions on this label).
- P330 Rinse mouth.
- P391 Collect spillage.
- P405 Store locked up.
AG490 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-428)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. De Vos J., Jourdan M., Tarte K., Jasmin C., & Klein B. (2000) British J. Haem. 109(4): 823–828.
3. Kirken R.A., et al. (1999) J. Leukocyte Biol. 65(6): 891–899.
