| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | AHGDM hydrochloride |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
Aminohexylgeldanamycin hydrochloride (CAS 1146534-45-3) is a research-grade small molecule supplied by TargetMol.
Alternative names: AHGDM hydrochloride
Physical Properties
| CAS Number | 1146534-45-3 |
|---|---|
| Molecular Formula | C34H53ClN4O8 |
| Molecular Weight | 681.27 g/mol |
| SMILES | Cl.CO(CH)1C(CH)(C)CC2=C(NCCCCCCN)C(=O)C=C(NC(=O)C(C)=C/C=C/(CH)(OC)(CH… |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Aminohexylgeldanamycin (AHGDM) hydrochloride is a Geldanamycin derivative and a powerful inhibitor of HSP90. It exhibits significant antiangiogenic and antitumor properties.
Target(s): Others, ADC Cytotoxin
Signaling pathway(s): Others, Antibody-drug Conjugate/ADC Related
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Use a bath-type ultrasonic cleaner at standard cleaning frequency (37–40 kHz). Bath sonication is gentler than a probe sonicator and avoids sample overheating. Sonicate in 5–10 second intervals, checking solubility between pulses, for no more than 2–3 minutes total. Warm the bath to 37 °C if solubility remains poor.
Insoluble impurities, which do not affect the product activity, are recommended to filter out or remove. We will investigate to confirm whether the impurity was introduced during packaging or if it is inherent to the product itself.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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