| Field | Specification |
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Compound Overview
Amodiaquine hydrochloride (CAS 69-44-3) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 69-44-3 |
|---|---|
| Molecular Formula | C20H24Cl3N3O |
| Molecular Weight | 428.78 g/mol |
| SMILES | CCN(CC)CC1=C(C=CC(=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O.Cl.Cl |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Amodiaquine dihydrochloride (Amodiaquin dihydrochloride), a member of the 4-aminoquinoline class, serves as an antimalarial agent and exhibits potent oral activity as a histamine N-methyltransferase inhibitor, displaying a K i value of 18.6 nM. Additionally, it acts as a Nurr1 agonist, targeting the Nurr1-LBD (ligand binding domain) with an EC 50 of approximately 20 uM, thereby demonstrating an anti-inflammatory effect (1) (2) (3) (4) (5).
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Centrifuge the closed vial at 3000 rpm for 1–2 minutes to consolidate the powder at the bottom. For electrostatically charged powders, briefly warm the vial to room temperature and allow it to equilibrate before opening. Then add the appropriate solvent directly onto the powder and vortex before sonicating. Avoid tapping the vial vigorously, as this can generate fine powder aerosol.
Use a bath-type ultrasonic cleaner at standard cleaning frequency (37–40 kHz). Bath sonication is gentler than a probe sonicator and avoids sample overheating. Sonicate in 5–10 second intervals, checking solubility between pulses, for no more than 2–3 minutes total. Warm the bath to 37 °C if solubility remains poor.
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