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Compound Overview
AMPK-α1β1γ1 activator 1 (CAS 1943510-86-8) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 1943510-86-8 |
|---|---|
| Molecular Formula | C25H24ClNO9 |
| Molecular Weight | 517.91 g/mol |
| SMILES | C(O(CH)1O(CH)(C(O)=O)(CH)(O)(CH)(O)(CH)1O)(=O)C=2C=3C(=CC(Cl)=C(C3)C4=… |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
AMPK-alpha1beta1gamma1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the beta1 isoforms of human AMPK with an EC50 of 38.1 nM through direct binding to the human AMPK alpha1beta1gamma1 isoform. It is utilized in diabetic nephropathy research (1).
Target(s): AMPK
Signaling pathway(s): Chromatin/Epigenetic, PI3K/Akt/mTOR signaling
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Most small molecule inhibitors are not compatible with autoclaving (121 °C), which can cause thermal decomposition or loss of biological activity. For sterile cell-based experiments, filter-sterilize working solutions through a 0.2 µm membrane after dilution into aqueous buffer. Verify thermal stability in the DataSheet before applying any heat treatment.
Use a bath-type ultrasonic cleaner at standard cleaning frequency (37–40 kHz). Bath sonication is gentler than a probe sonicator and avoids sample overheating. Sonicate in 5–10 second intervals, checking solubility between pulses, for no more than 2–3 minutes total. Warm the bath to 37 °C if solubility remains poor.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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