| Field | Specification |
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| Mfr No | |
| Activity | |
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| Signaling Pathway | |
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Compound Overview
Amyloid-β (1-8, A2V) Peptide is a research-grade small molecule supplied by TargetMol.
Physical Properties
| Form | Solid |
|---|---|
| Shipping | Room Temperature (RT) |
Biological Activity
Amyloid-beta (1-8, A2V) is a truncated form of amyloid-beta (Abeta) that contains a valine to alanine substitution at position 2 of the Abeta numbering convention (Abeta A2V), which corresponds to position 673 of the amyloid precursor protein (APP) numbering convention (APP A673V). An Abeta (1-40) (Abeta40) A2V peptide increases the production of Abeta and the rate and amount of amyloid fibril formation in vitro, effects that can be reduced by coincubation with wild-type Abeta40. Abeta40 and Abeta42 levels are increased in CHO cells expressing the Abeta A2V mutation and in fibroblasts derived from patients with the Abeta A2V mutation. As a homozygous mutation, Abeta A2V is correlated with Alzheimer's disease with distinctive pathological features, but disease does not develop in patients with a heterozygous Abeta A2V mutation.
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Use a bath-type ultrasonic cleaner rather than a high-intensity ultrasonic disruptor. Bath sonicators provide gentle, uniform agitation appropriate for dissolving solid compounds without generating cavitation damage or excessive heat. Ensure the solvent tube is fully submerged and use short sonication pulses of 5–10 seconds.
mg/mL (milligrams per milliliter) and mM (millimolar = millimoles per liter) are two concentration units for the same solution. To convert: mM = (mg/mL × 1000) / MW (g/mol). For example, for a compound with MW = 350 g/mol: 1 mg/mL = 1000/350 = 2.86 mM. Use the molar concentration calculator on the TargetMol website for quick conversions.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
