| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Choriogonadotropin subunit beta;CG-beta;Chorionic gonadotrophin chain beta;CGB;CGB3;CGB5;CGB7;CGB8; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Gene ID | |
| Host | |
| Immunogen | Purified human Chorionic Gonadotropin. |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Overview
Anti-Beta-HCG CGB Antibody (Monoclonal, PC-2) is an antibody targeting CGB. Common applications include IHC. Key specifications include host: Mouse; clonality: Monoclonal; clone: Clone: PC-2; isotype: Mouse IgG1; reactivity: Human; observed MW: 55 kDa; calculated MW: 17739 MW.
Boster Bio Anti-Beta-HCG CGB Antibody (Monoclonal, PC-2) catalog # MA1111. Tested in IHC applications. This antibody reacts with Human.
Key elements and design rationale
- Target: CGB — Choriogonadotropin subunit beta
- Antibody format: Host: Mouse; Clonality: Monoclonal; Clone: Clone: PC-2; Isotype: Mouse IgG1
- Species reactivity: Human
- Molecular weight guidance: Observed: 55 kDa; Calculated: 17739 MW
Specificity note: No cross reactivity with other proteins.
Biological background
Protein function (datasheet): Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.
Scientific background (datasheet): beta-HCG (beta-Human Chorionic Gonadotropin), also termed as Chorionic Gonadotropin, Beta Chain (CGB). It is encoded by a multigene cluster composed of six homologous sequences. And in the family of beta-containing glycoprotein hormones, beta-HCG is unique in that it contains an extension of 29 amino acids at its COOH end. beta-HCG is mapped to 19q13.32 and expressed in trophoblast and various malignant tumors promotes cellular motility in vivo. beta-HCG has a novel function in uterine adaptation to early pregnancy as well as in tumor development and underline the importance of HCG as an as yet unrecognized angiogenic factor.
Cellular localization (datasheet): Secreted.
Tissue details (datasheet): Placenta.
Sequence similarities (datasheet): Belongs to the glycoprotein hormones subunit beta family.
Research relevance and current trends
- Commonly studied in contexts related to Chromatin Remodeling,Co-Factors,Epigenetics and Nuclear Signaling,Transcription.
- Supports comparative expression analysis across conditions, genotypes, or treatments when paired with appropriate controls.
- Useful for confirming target presence and subcellular distribution using orthogonal readouts (e.g., microscopy vs. immunoblotting).
Common research applications
- Immunohistochemistry (IHC): Assess tissue distribution and cell-type patterns; interpret staining with appropriate negative controls and antigen context.
Notes for experimental interpretation
- Consider isoforms, post-translational modifications, and processing that can shift apparent molecular weight or localization.
- Cross-reactivity (datasheet): Cross-reactivities with LH, FSH and TSH are less than 0.3%.
- Use appropriate positive and negative controls (e.g., KO/KD, blocking peptide, or isotype controls) to support specificity interpretation.
As a monoclonal antibody, this reagent is expected to recognize a defined epitope, which can support consistency across lots when epitope accessibility is preserved.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
