| Field | Specification |
|---|---|
| Target | |
| Alternative names | CACNA1A; CACH4; CACN3; CACNL1A4; Voltage-dependent P/Q-type calcium channel subunit alpha-1A; Brain calcium channel I; BI; Calcium channel, L type, alpha-1 polypeptide isoform 4; Voltage-gated calcium channel subunit alpha Cav2.1 |
| UniProt # | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | E.coli-derived human CACNA1A recombinant protein (Position: K251-D2157). |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Lyophilized |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
This rabbit polyclonal antibody recognizes voltage-dependent P/Q-type calcium channel subunit alpha-1A (gene CACNA1A) in mouse and rat samples and is validated for Western blot and ELISA.
CACNA1A encodes the pore-forming alpha-1A subunit of P/Q-type (Cav2.1) voltage-gated calcium channels, which are concentrated at presynaptic terminals in the brain and cerebellum. These channels couple membrane depolarization to neurotransmitter release. Mutations cause episodic ataxia type 2, familial hemiplegic migraine type 1 and spinocerebellar ataxia type 6, so it is widely studied in neurology.
| Target | Voltage-dependent P/Q-type calcium channel subunit alpha-1A (gene CACNA1A; UniProt O00555, human) |
|---|---|
| Host / Clonality / Isotype | Rabbit / Polyclonal / Rabbit IgG |
| Reactivity | Mouse, Rat |
| Purification | Immunogen affinity purified |
| Form | Lyophilized |
| Formulation | Per vial: 4 mg trehalose; 0.9 mg NaCl; 0.2 mg Na2HPO4 |
| Reconstitution | 500 µg/mL after adding 0.2 mL distilled water |
| Storage | As supplied: −20 °C for up to 12 months from receipt. After reconstitution: 4 °C for up to 1 month, or aliquot and keep at −20 °C for up to 6 months. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 0.25–0.5 µg/mL (Mouse, Rat) |
|---|---|
| ELISA | 0.1–0.5 µg/mL |
Immunogen
Recombinant human CACNA1A fragment (Lys251–Asp2157), expressed in E. coli.
Reactivity Notes
The supplier lists reactivity with mouse and rat. UniProt places voltage-dependent P/Q-type calcium channel subunit alpha-1A in the cell membrane. Tissue expression noted by UniProt (human): Brain specific.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
