| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Caveolin-3;M-caveolin;CAV3; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Form | Liquid |
| Host | |
| Immunogen | A synthesized peptide derived from Caveolin-3 |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Storage | |
| Target | |
| UniProt # |
Overview
This product is an anti-CAV3 antibody for target detection and characterization. Key identifiers include host species: Rabbit; Monoclonal; clone 26C39; isotype IgG; reactivity: Human. Reported application contexts include WB, IHC, IP (as provided in the source record). Boster Bio Anti-Caveolin-3 Rabbit Monoclonal Antibody catalog # M00990-2. Tested in WB, IHC, IP applications. This antibody reacts with Human.
Key elements and design rationale
- Target: CAV3 (Caveolin-3).
- Antibody format: Monoclonal; clone 26C39; isotype IgG.
- Host: Rabbit.
- Species reactivity: Human (confirm in your model system with appropriate controls).
This description is intended to help interpret the antibody design and the biological context of the target using the fields provided in the catalog record, alongside general experimental considerations.
Biological background
CAV3 (protein: Glycogen synthase kinase-3 beta (gsk3b)) is a commonly studied target in molecular and cellular biology. Functional context (as provided): May act as a scaffolding protein within caveolar membranes. Interacts ly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Reported cellular localization context: Golgi apparatus membrane ; Peripheral membrane protein . Cell membrane ; Peripheral membrane protein . Membrane, caveola ; Peripheral membrane protein . Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). . Tissue expression notes (as provided): Expressed predominantly in muscle. .
Research relevance and current trends
- Research context keywords from the source record include: Tumor Biomarkers.
- Current studies often focus on connecting target abundance/localization to pathway perturbations across models, tissues, and cell states.
- Quantitative and multiplexed assays (e.g., imaging + immunoblot panels) are commonly used to compare phenotypes across conditions and time-courses.
Common research applications
- Western blotting (WB): assess relative target abundance across samples, treatments, or time-points.
- Immunohistochemistry (IHC): evaluate spatial distribution of target-positive staining in tissue architecture.
- Immunoprecipitation (IP): enrich target complexes for downstream immunoblot or interaction analyses.
Workflow ideas (metafield): Validate CAV3 antibody specificity using KO/KD control samples (WB/IF/IHC as appropriate), Detect CAV3 expression by Western blot in cell or tissue lysates, Detect CAV3 in FFPE tissue sections by immunohistochemistry, Enrich CAV3 by immunoprecipitation from lysates for downstream analysis
Notes for experimental interpretation
- Consider isoforms and post-translational modifications (PTMs) that may shift apparent molecular weight or epitope accessibility.
- Apparent molecular weight may vary by sample type and processing (observed MW: 17 kDa; calculated MW: 17259 MW).
- Control concepts: include appropriate negative controls (e.g., isotype, KO/KD samples) and orthogonal validation when feasible.
Additional product details (from the source record)
- Molecular weight (observed): 17 kDa
- Cellular localization (provided): Golgi apparatus membrane ; Peripheral membrane protein . Cell membrane ; Peripheral membrane protein . Membrane, caveola ; Peripheral membrane protein . Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). .
- Tissue details (provided): Expressed predominantly in muscle. .
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
