| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Coiled-coil domain-containing protein 6;Papillary thyroid carcinoma-encoded protein;Protein H4;CCDC6;D10S170, TST1; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of human CCDC6, identical to the related mouse sequence. |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Overview
This antibody is intended for detection of CCDC6 (Coiled-coil domain-containing protein 6) in biological samples using common immunoassay formats. It is typically selected based on target identity, species reactivity, clonality/clone information, and detection modality.
Vendor notes: Boster Bio Anti-CCDC6 Antibody Picoband® catalog # PB10050. Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key elements and design rationale
- Antibody format: Rabbit Polyclonal Rabbit IgG
- Immunogen / epitope context: A synthetic peptide corresponding to a sequence at the N-terminus of human CCDC6, identical to the related mouse sequence.
- Molecular weight context: reported MW: 66 kDa; calculated MW: 53291 MW
- Reactivity: Human,Rat
- Applications: Flow Cytometry, IF, ICC, WB
As a polyclonal antibody, the reagent recognizes multiple epitopes on the target, which can improve detection robustness but may increase sensitivity to sample-dependent epitope changes.
Biological background
Coiled-coil domain-containing protein 6; Coiled-coil domain-containing protein 6. Coiled-coil domain-containing protein 6 is a protein that in humans is encoded by the CCDC6 gene. This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma. Functional note: Reversible hydration of carbon dioxide. Reported localization: Cytoplasm. Cytoplasm, cytoskeleton . May be a cytoskeletal protein. Expression/tissue context: Ubiquitously expressed.
Research relevance and current trends
- DNA/RNA: Researchers commonly examine how CCDC6 (Coiled-coil domain-containing protein 6) relates to this theme using model systems and orthogonal readouts.
- DNA Damage & Repair: Researchers commonly examine how CCDC6 (Coiled-coil domain-containing protein 6) relates to this theme using model systems and orthogonal readouts.
- DNA Damage Response: Researchers commonly examine how CCDC6 (Coiled-coil domain-containing protein 6) relates to this theme using model systems and orthogonal readouts.
Common research applications
- Western blotting: compare relative CCDC6 (Coiled-coil domain-containing protein 6) levels across conditions; band patterns may reflect isoforms and processing.
- IF/ICC: evaluate subcellular localization and co-localization patterns; signal can depend on fixation/permeabilization and epitope accessibility.
- Flow cytometry: quantify target-positive populations and shifts in expression; gating strategy and background staining controls are essential.
Notes for experimental interpretation
- Specificity notes: No cross reactivity with other proteins.
- Cross-reactivity: No cross-reactivity with other proteins.
- Isoforms and PTMs: Apparent size and signal patterns can differ across splice isoforms, proteolytic processing, and post-translational modifications.
- Controls: Include an isotype control (as relevant), no-primary control for imaging, and orthogonal validation such as KD/KO samples when available.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
