| Field | Specification |
|---|---|
| Target | |
| Alternative names | Cyclin-dependent kinase 1;CDK1;2.7.11.22;2.7.11.23;Cell division control protein 2 homolog;Cell division protein kinase 1;p34 protein kinase;Cdk1;Cdc2, Cdc2a, Cdkn1; |
| Gene ID | |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | C-terminal two-thirds of Xenopus CDK1 expressed in E.coli. |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Lyophilized |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone A17 is a mouse monoclonal antibody that recognizes cyclin-dependent kinase 1 (gene Cdk1) in chicken, human and mouse samples and is validated for Western blot and IHC.
CDK1 (CDC2) is the cyclin-dependent kinase that drives cells into mitosis. Bound mainly to cyclin B, it phosphorylates many substrates that trigger nuclear envelope breakdown, chromosome condensation and spindle assembly, and it also helps regulate centrosome duplication, making it a central marker and target in cell cycle and cancer research.
| Target | Cyclin-dependent kinase 1 (gene Cdk1; UniProt P39951, rat) |
|---|---|
| Clone | A17 |
| Host / Clonality / Isotype | Mouse / Monoclonal / Mouse IgG2a |
| Reactivity | Chicken, Human, Mouse |
| Purification | Ascites |
| Form | Lyophilized |
| Formulation | 1.2% sodium acetate; 0.01 mg NaN3; plus stabilizers |
| Reconstitution | 100 µg/mL after adding 1 mL PBS |
| Storage | As supplied: −20 °C for up to 12 months from receipt. After reconstitution: 4 °C for up to 1 month, or aliquot and keep at −20 °C for up to 6 months. Avoid repeated freeze–thaw cycles. |
Validated Applications
| IHC (paraffin sections) | 1–2 µg/mL (Human, Chicken, Mouse) |
|---|---|
| Western blot | 0.5–1 µg/mL (Human, Chicken, Mouse) |
Immunogen
C-terminal two-thirds of Xenopus CDK1 expressed in E. coli.
Reactivity Notes
The supplier lists reactivity with chicken, human and mouse. UniProt places cyclin-dependent kinase 1 in the nucleus, cytoplasm and mitochondrion.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
Hanliang Sun et al. (2025) 5-Methylcytosine-modified circRNA-CCNL2 regulates vascular remdeling in hypoxic pulmonary hypertension through binding to FXR2. International Journal of Biological Macromolecules. 10.1016/j.ijbiomac.2025.139638
Hongrui Guo et al. (2015) Dietary NiCl2 causes G2/M cell cycle arrest in the broiler's kidney. Oncotarget. 10.18632/oncotarget.5934
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Hong Cai et al. (2017) Dehydrocostus Lactone Suppresses Proliferation of Human Chronic Myeloid Leukemia Cells Through Bcr/Abl-JAK/STAT Signaling Pathways. Journal of Cellular Biochemistry. 10.1002/jcb.25994
Youshe Ren et al. (2011) Effects of maternal and dietary selenium (Se-enriched yeast) on the expression of p34cdc2 and CyclinB1 of germ cells of their offspring in goats. Animal Reproduction Science. 10.1016/j.anireprosci.2011.01.002
Ping Lin et al. (2018) Prostate cancer cell proliferation is suppressed by microRNA‑3160‑5p via targeting of F‑box and WD repeat domain containing 8. Oncology Letters. 10.3892/ol.2018.8505
