| Field | Specification |
|---|---|
| Target | |
| Alternative names | Growth hormone receptor;GH receptor;Somatotropin receptor;Growth hormone-binding protein;GH-binding protein;GHBP;Serum-binding protein;Ghr; |
| Gene ID | |
| UniProt # | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthetic peptide corresponding to a sequence in the middle region of mouse Growth hormone receptor, identical to the related rat sequence. |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Lyophilized |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
This rabbit polyclonal antibody targets growth hormone receptor (gene Ghr) in mouse and rat samples and is validated for Western blot. The predicted molecular weight is 72.8 kDa, and the supplier reports an observed band at about 72 kDa.
The growth hormone receptor (GHR) is a cytokine-family receptor that binds pituitary growth hormone and drives postnatal body growth. Hormone binding activates JAK2 and STAT5 signaling, which induces genes such as IGF-1. A cleaved soluble form, growth hormone-binding protein, circulates in plasma, and GHR is widely studied in growth, metabolism and endocrine research.
| Target | Growth hormone receptor (gene Ghr; UniProt P16882, mouse) |
|---|---|
| Host / Clonality / Isotype | Rabbit / Polyclonal / Rabbit IgG |
| Reactivity | Mouse, Rat |
| Form | Lyophilized |
| Formulation | Per vial: 0.9 mg NaCl; 0.2 mg Na2HPO4; 0.05 mg thimerosal; 0.05 mg NaN3; plus stabilizers |
| Calculated MW | 72.8 kDa |
| Observed MW | 72 kDa |
| Storage | As supplied: −20 °C for up to 12 months from receipt. After reconstitution: 4 °C for up to 1 month, or aliquot and keep at −20 °C for up to 6 months. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 0.1–0.5 µg/mL (Mouse, Rat) |
|---|
Samples with a confirmed band (WB): rat liver tissue, rat kidney tissue, rat spleen tissue, rat intestine tissue, mouse spleen tissue, mouse testis tissue, mouse liver tissue, mouse kidney tissue, mouse intestine tissue.
Recommended loading (WB): 20–40 µg of total protein per lane.
Immunogen
Synthetic peptide from the middle region of mouse growth hormone receptor. The peptide sequence is conserved in rat.
Reactivity Notes
The supplier lists reactivity with mouse and rat. UniProt places growth hormone receptor in the cell membrane. Tissue expression noted by UniProt (mouse): Expressed in all tissues tested including, liver, heart, adipose tissue, mammary gland, testes, ovary, brain, kidney and muscle. The samples tested by the supplier (listed above) are a practical starting point for positive controls.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
Ting Xie et al. (2021) Mesenchymal growth hormone receptor deficiency leads to failure of alveolar progenitor cell function and severe pulmonary fibrosis. Science Advances. 10.1126/sciadv.abg6005
