| Field | Specification |
|---|---|
| Target | |
| Alternative names | Heparanase;3.2.1.166;Endo-glucoronidase;Heparanase 8 kDa subunit;Heparanase 50 kDa subunit;Hpse;Hpa; |
| UniProt # | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | E.coli-derived mouse Heparanase 1 recombinant protein (Position: K206-K457). Mouse Heparanase |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Lyophilized |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
This rabbit polyclonal antibody targets heparanase (gene Hpse) in mouse samples and is validated for Western blot.
Heparanase (HPSE) is the main mammalian enzyme that cuts heparan sulfate chains on proteoglycans in the extracellular matrix and on cell surfaces. This releases bound growth factors and cytokines and remodels the matrix, so heparanase is studied in inflammation, angiogenesis, tumor invasion and metastasis.
| Target | Heparanase (gene Hpse; UniProt Q6YGZ1, mouse) |
|---|---|
| Host / Clonality / Isotype | Rabbit / Polyclonal / Rabbit IgG |
| Reactivity | Mouse |
| Purification | Immunogen affinity purified |
| Form | Lyophilized |
| Formulation | Per vial: 4 mg trehalose; 0.9 mg NaCl; 0.2 mg Na2HPO4; 0.05 mg NaN3 |
| Reconstitution | 500 µg/mL after adding 0.2 mL distilled water |
| Storage | As supplied: −20 °C for up to 12 months from receipt. After reconstitution: 4 °C for up to 1 month, or aliquot and keep at −20 °C for up to 6 months. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 0.1–0.5 µg/mL (Mouse) |
|---|
Immunogen
Recombinant mouse Heparanase 1 fragment (Lys206–Lys457), expressed in E. coli.
Reactivity Notes
The supplier lists reactivity with mouse. UniProt describes heparanase as secreted and also located in the lysosome membrane and nucleus. Tissue expression noted by UniProt (mouse): Expressed in skin, mainly in the stratum granulosum and the first layer of the stratum corneum in the upper part of the epidermis.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.