| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | 28C5, termed IC14 |
| Cas No. | |
| Clonality | |
| Expression System | |
| Form | Liquid |
| Host | |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Product Overview
Research Grade Atibuclimab (HY038016) is a chimeric monoclonal antibody detecting Myeloid cell-specific leucine-rich glycoprotein in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Human. Highlights- ●Multi-Application — Validated across multiple applications.
Specifications
| Host Species | Chimeric |
|---|---|
| Species Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | IgG4, kappa |
| Target | Myeloid cell-specific leucine-rich glycoprotein, CD14, Monocyte differentiation antigen CD14 |
| Purification | Protein A/G purified from cell culture supernatant. |
| Purity | >95% purity as determined by SDS-PAGE. |
| Form | Liquid |
| Storage Buffer | 0.01M PBS, pH 7.4. |
| Expression System | Mammalian Cells |
| UniProt | P08571 |
Validated Applications
| Application |
|---|
| ELISA |
| Flow Cytometry |
| Functional Assay |
| In Vivo Studies |
Scientific Background
Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein,CD14,Monocyte differentiation antigen CD14) is a ~40 kDa protein. Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
Reactivity
This antibody shows reactivity with Human.
Safety & Handling
Customization & Add-ons: Can't find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
1. Wright, SD. et al. (1990) Science (New York, N.Y.) 249, 1431-3. PMID: 1698311
2. Kelley, SL. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 190, 1304-11. PMID: 23264655
3. Tsukamoto, H. et al. (2010) International immunology 22, 271-80. PMID: 20133493
4. Murakami, K. et al. (2012) FEBS letters 586, 319-24. PMID: 22265692
5. Haziot, A. et al. (1996) Immunity 4, 407-14. PMID: 8612135
6. Triantafilou, M. et al. (2006) The Journal of biological chemistry 281, 31002-11. PMID: 16880211
7. Estruch, M. et al. (2013) Atherosclerosis 229, 356-62. PMID: 23880187
