| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Peptidyl-prolyl cis-trans isomerase A;PPIase A;5.2.1.8;Cyclophilin A;Cyclosporin A-binding protein;Rotamase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;PPIA;CYPA; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Form | Liquid |
| Host | |
| Immunogen | A synthesized peptide derived from human IL17A Receptor |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Storage | |
| Target | |
| UniProt # |
Overview
This product is an anti-IL17RA antibody for target detection and characterization. Key identifiers include host species: Rabbit; Monoclonal; clone 24I08; isotype IgG; reactivity: Human. Reported application contexts include WB, IP (as provided in the source record). Boster Bio Anti-IL17A Receptor Rabbit Monoclonal Antibody catalog # M01311. Tested in WB, IP applications. This antibody reacts with Human.
Key elements and design rationale
- Target: IL17RA (Peptidyl-prolyl cis-trans isomerase A).
- Antibody format: Monoclonal; clone 24I08; isotype IgG.
- Host: Rabbit.
- Species reactivity: Human (confirm in your model system with appropriate controls).
This description is intended to help interpret the antibody design and the biological context of the target using the fields provided in the catalog record, alongside general experimental considerations.
Biological background
IL17RA (protein: Glycogen synthase kinase-3 beta (gsk3b)) is a commonly studied target in molecular and cellular biology. Functional context (as provided): PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Reported cellular localization context: Cytoplasm . Secreted . Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation. Tissue expression notes (as provided): Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system.
Research relevance and current trends
- Research context keywords from the source record include: Cell Biology.
- Current studies often focus on connecting target abundance/localization to pathway perturbations across models, tissues, and cell states.
- Quantitative and multiplexed assays (e.g., imaging + immunoblot panels) are commonly used to compare phenotypes across conditions and time-courses.
Common research applications
- Western blotting (WB): assess relative target abundance across samples, treatments, or time-points.
- Immunoprecipitation (IP): enrich target complexes for downstream immunoblot or interaction analyses.
Workflow ideas (metafield): Validate IL17RA antibody specificity using KO/KD control samples (WB/IF/IHC as appropriate), Detect IL17RA expression by Western blot in cell or tissue lysates, Enrich IL17RA by immunoprecipitation from lysates for downstream analysis
Notes for experimental interpretation
- Consider isoforms and post-translational modifications (PTMs) that may shift apparent molecular weight or epitope accessibility.
- Apparent molecular weight may vary by sample type and processing (observed MW: 120-160 kDa; calculated MW: 18012 MW).
- Control concepts: include appropriate negative controls (e.g., isotype, KO/KD samples) and orthogonal validation when feasible.
Additional product details (from the source record)
- Molecular weight (observed): 120-160 kDa
- Cellular localization (provided): Cytoplasm . Secreted . Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.
- Tissue details (provided): Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
