| Field | Specification |
|---|---|
| Target | |
| Alternative names | Insulin-2;Insulin-2 B chain;Insulin-2 A chain;Ins2;Ins-2; |
| Gene ID | |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | Human insulin. |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Lyophilized |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone K36AC10 is a mouse monoclonal antibody that recognizes insulin-2 (gene Ins2) in human, rabbit and rat samples and is validated for IHC.
In rat, insulin-2 (Ins2) is one of two insulin genes, both expressed in pancreatic beta cells. Like insulin in other species, the mature hormone lowers blood glucose by promoting glucose uptake into tissues and glycogen synthesis in the liver, and it is widely studied in rodent models of diabetes and metabolism.
| Target | Insulin-2 (gene Ins2; UniProt P01323, rat) |
|---|---|
| Clone | K36AC10 |
| Host / Clonality / Isotype | Mouse / Monoclonal / Mouse IgG1 |
| Reactivity | Human, Rabbit, Rat |
| Purification | Ascites |
| Form | Lyophilized |
| Formulation | 1.2% sodium acetate; 0.01 mg NaN3; plus stabilizers |
| Reconstitution | 100 µg/mL after adding 1 mL PBS |
| Storage | As supplied: −20 °C for up to 12 months from receipt. After reconstitution: 4 °C for up to 1 month, or aliquot and keep at −20 °C for up to 6 months. Avoid repeated freeze–thaw cycles. |
Validated Applications
| IHC (paraffin sections) | 0.4–1 µg/mL (Human, Rabbit, Rat) |
|---|
Immunogen
Human insulin.
Reactivity Notes
The supplier lists reactivity with human, rabbit and rat. UniProt describes insulin-2 as a secreted protein.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
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Lei Chen et al. (2022) Peripheral Gonadotropin-Inhibitory Hormone (GnIH) Acting as a Novel Modulator Involved in Hyperphagia-Induced Obesity and Associated Disorders of Metabolism in an In Vivo Female Piglet Model. International Journal of Molecular Sciences. 10.3390/ijms232213956
Shen Lan et al. (2010) NDRG2 is highly expressed in pancreatic β cells and involved in protection against lipotoxicity. Cellular and Molecular Life Sciences. 10.1007/s00018-010-0258-1
Cuihong Chen et al. (2018) Effects of Irbesartan Pretreatment on Pancreatic β-Cell Apoptosis in STZ-Induced Acute Prediabetic Mice. Oxidative Medicine and Cellular Longevity. 10.1155/2018/8616194
Xue Zhang et al. (2016) Beyond knockout: A novel homodimerization-targeting MyD88 inhibitor prevents and cures type 1 diabetes in NOD mice. Metabolism-Clinical and Experimental. 10.1016/j.metabol.2016.05.005
