| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Relaxin receptor 2; G-protein coupled receptor 106; G-protein coupled receptor affecting testicular descent; Leucine-rich repeat-containing G-protein coupled receptor 8; Relaxin family peptide receptor 2; RXFP2; GPR106; GREAT; LGR8 |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | E.coli-derived human JDP2 recombinant protein (Position: E33-K163). |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Overview
Anti-JDP2 Antibody Picoband® is an antibody for JDP2 detection raised in Rabbit (Polyclonal, Rabbit IgG), with reported reactivity: Human. Commonly used in WB, IHC, Flow Cytometry, ELISA workflows.
Key elements and design rationale
- Target: JDP2 (relaxin family peptide receptor 2); UniProt: Q8WYK2
- Antibody format: Rabbit, Polyclonal, Rabbit IgG
- Molecular weight: 19 kDa, calculated 35883 MW
- Applications: WB, IHC, Flow Cytometry, ELISA
Vendor description (summary): Boster Bio Anti-JDP2 Antibody Picoband® catalog # A04870-2.
Biological background
Biological context: Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).
Expression and localization notes: cellular localization: Cell membrane; Multi-pass membrane protein., tissue context: Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow..
Common research applications
- Western blotting (WB): Compare JDP2 levels across samples and conditions using appropriate loading and biological controls.
- Immunohistochemistry (IHC): Evaluate spatial distribution of JDP2 in tissue sections, considering fixation and antigen retrieval effects.
- Flow cytometry: Quantify JDP2-positive populations in single-cell suspensions with appropriate gating and controls.
- ELISA: Use antibody-based detection formats to assess antigen presence or binding in plate-based assays.
Notes for experimental interpretation
- Account for isoforms, post-translational modifications, and sample-specific processing that can shift apparent molecular weight or epitope accessibility.
- Use positive/negative biological controls where possible (e.g., known-expressing cells/tissues, knockdown/knockout models) and include appropriate secondary-only/isotype controls for imaging workflows.
Additional product notes (from provided fields)
- Background: Jun dimerization protein 2 (JUNDM2) is a protein that in humans is encoded by the JDP2 gene. Mouse Jdp2 is an inhibitory subunit of the differentiation regulatory factor (DRF) complex. Jdp2 repressed retinoic acid-induced transcription of the Jun gene by recruiting a histone deacetylase-3 -containing complex to the differentiation response element (DRE) of the Jun promoter. Expression of JDP2 was reduced in several human cancers compared with matched normal tissues. Human JDP2 has antitumorigenic properties.
- Cross reactivity: No cross-reactivity with other proteins.
- Cellular localization: Cell membrane; Multi-pass membrane protein.
- Tissue details: Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow.
- Research category: Endocrine System,G Protein Signaling,More Gpcr,Neuroscience,Neurotransmission,Receptors / Channels,Signal Transduction,Signaling Pathway
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
