| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Kallikrein-4;3.4.21.-;Enamel matrix serine proteinase 1;Kallikrein-like protein 1;KLK-L1;Prostase;Serine protease 17;KLK4;EMSP1, PRSS17, PSTS; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | E.coli-derived human Kallikrein 4 recombinant protein (Position: I31-S254). |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Overview
This antibody is intended for detection of KLK4 (Kallikrein-4) in biological samples using common immunoassay formats. It is typically selected based on target identity, species reactivity, clonality/clone information, and detection modality.
Vendor notes: Boster Bio Anti-Kallikrein 4/KLK4 Antibody Picoband® catalog # PB9260. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key elements and design rationale
- Antibody format: Rabbit Polyclonal Rabbit IgG
- Immunogen / epitope context: E.coli-derived human Kallikrein 4 recombinant protein (Position: I31-S254). (reported region: I31-S254).
- Molecular weight context: reported MW: 27 kDa; calculated MW: 27032 MW
- Reactivity: Human
- Applications: WB
As a polyclonal antibody, the reagent recognizes multiple epitopes on the target, which can improve detection robustness but may increase sensitivity to sample-dependent epitope changes.
Biological background
Kallikrein-4; Kallikrein-4. Kallikrein-related peptidase 4, also known as PSTS or EMSP1, is a protein which in humans is encoded by the KLK4 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. In particular, they may serve as biomarkers for both prostate cancer and breast cancer. It has been found that KLK4 is a proliferative factor with effects on gene expression and it may have a role in prostate cancer development and progression. Functional note: Involved in enamel formation. . Reported localization: Secreted. Expression/tissue context: Expressed in prostate.
Research relevance and current trends
- Cancer: Researchers commonly examine how KLK4 (Kallikrein-4) relates to this theme using model systems and orthogonal readouts.
- Cytoskeleton/ECM: Researchers commonly examine how KLK4 (Kallikrein-4) relates to this theme using model systems and orthogonal readouts.
- ECM Enzymes: Researchers commonly examine how KLK4 (Kallikrein-4) relates to this theme using model systems and orthogonal readouts.
Common research applications
- Western blotting: compare relative KLK4 (Kallikrein-4) levels across conditions; band patterns may reflect isoforms and processing.
Notes for experimental interpretation
- Specificity notes: No cross reactivity with other proteins.
- Cross-reactivity: No cross-reactivity with other proteins
- Family / similarity context: Belongs to the peptidase S1 family. Kallikrein subfamily.
- Isoforms and PTMs: Apparent size and signal patterns can differ across splice isoforms, proteolytic processing, and post-translational modifications.
- Controls: Include an isotype control (as relevant), no-primary control for imaging, and orthogonal validation such as KD/KO samples when available.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
