| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Laminin subunit beta-2;Laminin chain B3;Laminin-11 subunit beta;Laminin-14 subunit beta;Laminin-15 subunit beta;Laminin-3 subunit beta;Laminin-4 subunit beta;Laminin-7 subunit beta;Laminin-9 subunit beta;S-laminin subunit beta;S-LAM beta;Lamb2; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Gene ID | |
| Host | |
| Immunogen | Human laminin. |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Overview
Anti-Laminin LAMA1 Monoclonal Antibody is an antibody targeting LAMA1; LAMA2; LAMB1; LAMB2. Common applications include IHC. Key specifications include host: Mouse; clonality: Monoclonal; clone: Clone: LAM-89; isotype: Mouse IgG1; reactivity: Human,Pig; observed MW: 68 kDa; calculated MW: 196474 MW.
Boster Bio Anti-Laminin LAMA1 Monoclonal Antibody catalog # MA1054. Tested in IHC applications. This antibody reacts with Human, Pig.
Key elements and design rationale
- Target: LAMA1; LAMA2; LAMB1; LAMB2 — Laminin subunit beta-2
- Antibody format: Host: Mouse; Clonality: Monoclonal; Clone: Clone: LAM-89; Isotype: Mouse IgG1
- Species reactivity: Human,Pig
- Molecular weight guidance: Observed: 68 kDa; Calculated: 196474 MW
Specificity note: No cross reactivity with other proteins.
Biological background
Protein function (datasheet): Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Scientific background (datasheet): Laminin is a heterotrimeric extracellular matrix protein consisting of 3 chains: alpha-1,beta-1 and gamma-1, formerly called beta-2 (LAMA2). This gene is over 260,000 base pairs and contains 64 exons. Laminin is similar with merosin, a basement membrane-associated protein found in placenta, striated muscle, and peripheral nerve, and both of them are members of the same family of basement membrane proteins. And merosin is the same as laminin M, a striated muscle-specific, basal-lamina-associated protein, it may play a primary role in the pathogenesis of that disorder.
Cellular localization (datasheet): Secreted, extracellular space, extracellular matrix, basement membrane.
Tissue details (datasheet): Found in the basement membranes (major component). S-laminin is concentrated in the synaptic cleft of the neuromuscular junction.
Sequence similarities (datasheet): Contains 17 laminin EGF-like domains.
Research relevance and current trends
- Commonly studied in contexts related to Angiogenesis,Cardiovascular,Cell Adhesion Proteins,Cytoskeleton/ECM,ECM Proteins,Extracellular Matrix,Intermediate Filaments,Neuroscience,Signal Transduction.
- Supports comparative expression analysis across conditions, genotypes, or treatments when paired with appropriate controls.
- Useful for confirming target presence and subcellular distribution using orthogonal readouts (e.g., microscopy vs. immunoblotting).
Common research applications
- Immunohistochemistry (IHC): Assess tissue distribution and cell-type patterns; interpret staining with appropriate negative controls and antigen context.
Notes for experimental interpretation
- Consider isoforms, post-translational modifications, and processing that can shift apparent molecular weight or localization.
- Cross-reactivity (datasheet): No cross-reactivity with other proteins
- Use appropriate positive and negative controls (e.g., KO/KD, blocking peptide, or isotype controls) to support specificity interpretation.
As a monoclonal antibody, this reagent is expected to recognize a defined epitope, which can support consistency across lots when epitope accessibility is preserved.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
