| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Microtubule-associated protein 2;MAP-2;Map2;Mtap2; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Gene ID | |
| Host | |
| Immunogen | Rat brain microtubule-associated proteins (MAPs). |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Overview
Anti-MAP2 Antibody (Monoclonal, HM-2) is an antibody targeting MAP2. Common applications include WB, IHC. Key specifications include host: Mouse; clonality: Monoclonal; clone: Clone: HM-2; isotype: Mouse IgG1; reactivity: Human,Mouse,Rat; observed MW: 280 kDa; calculated MW: 202411 MW.
Boster Bio Anti-MAP2 Antibody (Monoclonal, HM-2) catalog # MA1057. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Key elements and design rationale
- Target: MAP2 — Microtubule-associated protein 2
- Antibody format: Host: Mouse; Clonality: Monoclonal; Clone: Clone: HM-2; Isotype: Mouse IgG1
- Species reactivity: Human,Mouse,Rat
- Molecular weight guidance: Observed: 280 kDa; Calculated: 202411 MW
Specificity note: No cross reactivity with other proteins.
Biological background
Protein function (datasheet): The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
Scientific background (datasheet): MAP2, a 280-kD protein, is highly concentrated in neuronal somata and dendrites. Microtubule-associated protein 2 (MAP2)is a neurosteroid receptor. MAP2 gene contains 19 exons, and located in segment 2q34-q35. The transgenic MAP2c was present in dendrites but not in axons but transgenic MAP2c messenger RNA was limited to cell bodies.
Cellular localization (datasheet): Cytoplasm, cytoskeleton .
Sequence similarities (datasheet): Contains 3 Tau/MAP repeats.
Research relevance and current trends
- Commonly studied in contexts related to Cell Type Marker,Cytoskeleton,Cytoskeleton/ECM,Microtubules,Neural Stem Cells,Neuron Marker,Neuroscience,Signal Transduction,Stem Cells.
- Supports comparative expression analysis across conditions, genotypes, or treatments when paired with appropriate controls.
- Useful for confirming target presence and subcellular distribution using orthogonal readouts (e.g., microscopy vs. immunoblotting).
Common research applications
- Western blot (WB): Compare relative target abundance and apparent size/isoforms across samples; interpret bands in light of expected MW and potential PTMs.
- Immunohistochemistry (IHC): Assess tissue distribution and cell-type patterns; interpret staining with appropriate negative controls and antigen context.
Notes for experimental interpretation
- Consider isoforms, post-translational modifications, and processing that can shift apparent molecular weight or localization.
- Cross-reactivity (datasheet): No cross-reactivity with other proteins
- Use appropriate positive and negative controls (e.g., KO/KD, blocking peptide, or isotype controls) to support specificity interpretation.
As a monoclonal antibody, this reagent is expected to recognize a defined epitope, which can support consistency across lots when epitope accessibility is preserved.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
