| Field | Specification |
|---|---|
| Target | |
| Alternative names | Metabotropic glutamate receptor 3; mGluR3; GRM3; GPRC1C |
| Gene ID | |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human mGluR3 |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone 26G13 is a rabbit monoclonal antibody that recognizes metabotropic glutamate receptor 3 (gene GRM3) in human, mouse and rat samples and is validated for Western blot. The predicted molecular weight is 98.9 kDa, and the supplier reports an observed band at about 330 kDa.
Metabotropic glutamate receptor 3 (mGluR3, GRM3) is a group II G protein-coupled receptor that responds to glutamate by inhibiting adenylyl cyclase through Gi/o proteins. It is expressed on neurons and glial cells, including astrocytes, where it helps regulate glutamate signaling. GRM3 is studied in synaptic modulation, neuroprotection and psychiatric genetics.
| Target | Metabotropic glutamate receptor 3 (gene GRM3; UniProt Q14832, human) |
|---|---|
| Clone | 26G13 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / IgG |
| Reactivity | Human, Mouse, Rat |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 98.9 kDa |
| Observed MW | 330 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|
Samples with a confirmed band (WB): human cerebellum.
Recommended loading (WB): 20–40 µg of total protein per lane.
Immunogen
Synthetic peptide based on the sequence of human mGluR3.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt places metabotropic glutamate receptor 3 in the cell membrane. Tissue expression noted by UniProt (human): Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala. The samples tested by the supplier (listed above) are a practical starting point for positive controls.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
