| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | MAGUK p55 subfamily member 2;Discs large homolog 2;Protein MPP2;MPP2;DLG2; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Gene ID | |
| Host | |
| Immunogen | E. coli-derived human MPP2 recombinant protein (Position: R387-Y576). Human MPP2 shares 96.8% amino acid (aa) sequence identity with mouse MPP2. |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Overview
This antibody is intended for detection of MPP2 (MAGUK p55 subfamily member 2) in biological samples using common immunoassay formats. It is typically selected based on target identity, species reactivity, clonality/clone information, and detection modality.
Vendor notes: Boster Bio Anti-MPP2 Antibody Picoband® catalog # PB10079. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key elements and design rationale
- Antibody format: Rabbit Polyclonal Rabbit IgG
- Immunogen / epitope context: E. coli-derived human MPP2 recombinant protein (Position: R387-Y576). Human MPP2 shares 96.8% amino acid (aa) sequence identity with mouse MPP2. (reported region: R387-Y576).
- Molecular weight context: reported MW: 55 kDa; calculated MW: 64581 MW
- Reactivity: Human,Mouse,Rat
- Applications: WB
As a polyclonal antibody, the reagent recognizes multiple epitopes on the target, which can improve detection robustness but may increase sensitivity to sample-dependent epitope changes.
Biological background
MAGUK p55 subfamily member 2; MAGUK p55 subfamily member 2. MAGUK p55 subfamily member 2 is a protein that in humans is encoded by the MPP2 gene. Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. Functional note: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity). . Reported localization: Membrane; Lipid-anchor. Cell projection, stereocilium . Colocalizes with WHRN at stereocilium tip during hair cell development (By similarity). Colocalizes with MPP5 in the retina, at the outer limiting membrane (OLM). Colocalizes with WHRN in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium (CC). Colocalizes with NF2 in non- myelin-forming Schwann cells. . Expression/tissue context: Ubiquitous. .
Research relevance and current trends
- Adapters: Researchers commonly examine how MPP2 (MAGUK p55 subfamily member 2) relates to this theme using model systems and orthogonal readouts.
- Signal Transduction: Researchers commonly examine how MPP2 (MAGUK p55 subfamily member 2) relates to this theme using model systems and orthogonal readouts.
- Transmembrane: Researchers commonly examine how MPP2 (MAGUK p55 subfamily member 2) relates to this theme using model systems and orthogonal readouts.
Common research applications
- Western blotting: compare relative MPP2 (MAGUK p55 subfamily member 2) levels across conditions; band patterns may reflect isoforms and processing.
Notes for experimental interpretation
- Specificity notes: No cross reactivity with other proteins.
- Cross-reactivity: No cross-reactivity with other proteins.
- Isoforms and PTMs: Apparent size and signal patterns can differ across splice isoforms, proteolytic processing, and post-translational modifications.
- Controls: Include an isotype control (as relevant), no-primary control for imaging, and orthogonal validation such as KD/KO samples when available.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
