| Field | Specification |
|---|---|
| Target | |
| Alternative names | ATP-binding cassette sub-family C member 5; Multi-specific organic anion transporter C; MOAT-C; Multidrug resistance-associated protein 5; SMRP; pABC11; ABCC5; MRP5 |
| UniProt # | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | E.coli-derived human MRP5/ABCC5 recombinant protein (Position: K647-D1409). |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Lyophilized |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
This rabbit polyclonal antibody detects ATP-binding cassette sub-family C member 5 (gene ABCC5) in human samples and is validated for IHC, flow cytometry and ELISA. The predicted molecular weight is 160.7 kDa.
MRP5 (ABCC5) is an ATP-dependent transporter that exports cyclic nucleotides such as cAMP and cGMP, glutamate conjugates and several drugs from cells. It is widely expressed and is studied in nucleotide signaling and resistance to nucleoside-analog drugs.
| Target | ATP-binding cassette sub-family C member 5 (gene ABCC5; UniProt O15440, human) |
|---|---|
| Host / Clonality / Isotype | Rabbit / Polyclonal / Rabbit IgG |
| Reactivity | Human |
| Form | Lyophilized |
| Formulation | Per vial: 4 mg trehalose; 0.9 mg NaCl; 0.2 mg Na2HPO4; 0.01 mg NaN3 |
| Calculated MW | 160.7 kDa |
| Storage | As supplied: −20 °C for up to 12 months from receipt. After reconstitution: 4 °C for up to 1 month, or aliquot and keep at −20 °C for up to 6 months. Avoid repeated freeze–thaw cycles. |
Validated Applications
| IHC (paraffin sections) | 2–5 µg/mL (Human) |
|---|---|
| Flow cytometry (fixed cells) | 1–3 µg/1×106 cells (Human) |
| ELISA | 0.1–0.5 µg/mL |
Samples with confirmed staining (IHC): human gastric cancer tissue, human mammary cancer tissue.
Recommended antigen retrieval: heat-mediated, in TE buffer (pH 9.0); citrate buffer (pH 6.0) can be used instead.
Conditions in the example images (IHC): heat-mediated antigen retrieval in EDTA buffer (pH 8.0).
Samples with a confirmed signal (flow cytometry): PC-3 cells.
Immunogen
Recombinant human MRP5/ABCC5 fragment (Lys647–Asp1409), expressed in E. coli.
Reactivity Notes
The supplier lists reactivity with human. UniProt places ATP-binding cassette sub-family C member 5 in the basolateral cell membrane, Golgi apparatus lumen, endosome membrane and cytoplasmic granule. Tissue expression noted by UniProt (human): Predominant isoform in retinal pigment epithelium, bladder, and stomach...
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
