| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Natural cytotoxicity triggering receptor 1; Lymphocyte antigen 94 homolog; NK cell-activating receptor; Natural killer cell p46-related protein; NK-p46; NKp46; hNKp46; CD335; NCR1; LY94 |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | E. coli-derived human NCR1 recombinant protein (Position: Q22-R258). |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Overview
This antibody is intended for detection of NCR1 (Platelet endothelial cell adhesion molecule) in biological samples using common immunoassay formats. It is typically selected based on target identity, species reactivity, clonality/clone information, and detection modality.
Vendor notes: Boster Bio Anti-NCR1 Antibody Picoband® catalog # A01516-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key elements and design rationale
- Antibody format: Rabbit Polyclonal Rabbit IgG
- Immunogen / epitope context: E. coli-derived human NCR1 recombinant protein (Position: Q22-R258). (reported region: Q22-R258).
- Molecular weight context: reported MW: 36 kDa; calculated MW: nan
- Reactivity: Human,Mouse,Rat
- Applications: ELISA, IHC, WB
As a polyclonal antibody, the reagent recognizes multiple epitopes on the target, which can improve detection robustness but may increase sensitivity to sample-dependent epitope changes.
Biological background
Platelet endothelial cell adhesion molecule; natural cytotoxicity triggering receptor 1. Natural cytotoxicity triggering receptor 1, also known as NKp46, is a protein that in humans is encoded by the NCR1 gene. This gene is mapped to chromosome 19, where genes encoding other NK inhibitory and activator structures are also located. NKP46 participates in NK-cell-mediated lysis of cells infected with an intracellular bacterium and that reduced functional capacity of NK cells is associated with severe manifestations of infectious disease. Functional note: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Reported localization: Cell membrane; Single-pass type I membrane protein. Expression/tissue context: Selectively expressed by both resting and activated NK cells.
Research relevance and current trends
- Adapters: Researchers commonly examine how NCR1 (Platelet endothelial cell adhesion molecule) relates to this theme using model systems and orthogonal readouts.
- Adaptive Immunity: Researchers commonly examine how NCR1 (Platelet endothelial cell adhesion molecule) relates to this theme using model systems and orthogonal readouts.
- Immunology: Researchers commonly examine how NCR1 (Platelet endothelial cell adhesion molecule) relates to this theme using model systems and orthogonal readouts.
Common research applications
- Western blotting: compare relative NCR1 (Platelet endothelial cell adhesion molecule) levels across conditions; band patterns may reflect isoforms and processing.
- IHC/IHC-F: assess spatial distribution of NCR1 (Platelet endothelial cell adhesion molecule) across tissue regions and cell types using matched controls.
- ELISA-compatible use: when applicable, interpret signal as relative abundance across sample sets with consistent handling and dilution strategy.
Notes for experimental interpretation
- Specificity notes: No cross reactivity with other proteins.
- Cross-reactivity: No cross-reactivity with other proteins.
- Isoforms and PTMs: Apparent size and signal patterns can differ across splice isoforms, proteolytic processing, and post-translational modifications.
- Controls: Include an isotype control (as relevant), no-primary control for imaging, and orthogonal validation such as KD/KO samples when available.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
