| Field | Specification |
|---|---|
| Target | |
| Alternative names | Neuronal PAS domain-containing protein 2;Neuronal PAS2;Basic-helix-loop-helix-PAS protein MOP4;Class E basic helix-loop-helix protein 9;bHLHe9;Member of PAS protein 4;PAS domain-containing protein 4;NPAS2;BHLHE9, MOP4, PASD4; |
| UniProt # | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | E. coli-derived human NPAS2 recombinant protein (Position: D474-Q578). Human NPAS2 shares 88.1% amino acid (aa) sequence identity with mouse NPAS2. |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Lyophilized |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
This rabbit polyclonal antibody recognizes neuronal PAS domain-containing protein 2 (gene NPAS2) in human, mouse and rat samples and is validated for Western blot.
NPAS2 is a bHLH-PAS transcription factor that pairs with BMAL1 to activate E-box-driven clock genes such as PER and CRY. It can partly substitute for CLOCK in the core circadian loop, particularly in forebrain neurons, and it has been linked to sleep regulation and metabolic rhythms. NPAS2 is studied in circadian biology.
| Target | Neuronal PAS domain-containing protein 2 (gene NPAS2; UniProt Q99743, human) |
|---|---|
| Host / Clonality / Isotype | Rabbit / Polyclonal / Rabbit IgG |
| Reactivity | Human, Mouse, Rat |
| Purification | Immunogen affinity purified |
| Form | Lyophilized |
| Formulation | Per vial: 4 mg trehalose; 0.9 mg NaCl; 0.2 mg Na2HPO4; 0.05 mg NaN3 |
| Reconstitution | 500 µg/mL after adding 0.2 mL distilled water |
| Storage | As supplied: −20 °C for up to 12 months from receipt. After reconstitution: 4 °C for up to 1 month, or aliquot and keep at −20 °C for up to 6 months. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 0.1–0.5 µg/mL (Human, Mouse, Rat) |
|---|
Immunogen
Recombinant human NPAS2 fragment (Asp474–Gln578), expressed in E. coli. Sequence identity with the mouse ortholog: 88.1%.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt places neuronal PAS domain-containing protein 2 in the nucleus.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
