| Field | Specification |
|---|---|
| Target | |
| Alternative names | Oxysterols receptor LXR-alpha; Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3; NR1H3; LXRA |
| UniProt # | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | E.coli-derived human NR1H3 recombinant protein (Position: D11-R401). Human NR1H3 shares |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Lyophilized |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
This rabbit polyclonal antibody detects oxysterols receptor LXR-alpha (gene NR1H3) in human, mouse and rat samples and is validated for Western blot, flow cytometry and ELISA.
LXRα (NR1H3) is an oxysterol-sensing nuclear receptor that pairs with RXR to control genes of cholesterol transport, fatty acid synthesis and inflammation. It is abundant in liver, adipose tissue and macrophages, where it drives cholesterol efflux genes such as ABCA1. It is studied in atherosclerosis, lipid metabolism and immune regulation.
| Target | Oxysterols receptor LXR-alpha (gene NR1H3; UniProt Q13133, human) |
|---|---|
| Host / Clonality / Isotype | Rabbit / Polyclonal / IgG |
| Reactivity | Human, Mouse, Rat |
| Purification | Immunogen affinity purified |
| Form | Lyophilized |
| Formulation | Per vial: 4 mg trehalose; 0.9 mg NaCl; 0.2 mg Na2HPO4 |
| Reconstitution | 500 µg/mL after adding 0.2 mL distilled water |
| Storage | As supplied: −20 °C for up to 12 months from receipt. After reconstitution: 4 °C for up to 1 month, or aliquot and keep at −20 °C for up to 6 months. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 0.25–0.5 µg/mL (Human, Mouse, Rat) |
|---|---|
| Flow cytometry (fixed cells) | 1–3 µg/1×106 cells (Human) |
| ELISA | 0.1–0.5 µg/mL |
Immunogen
Recombinant human NR1H3 fragment (Asp11–Arg401), expressed in E. coli.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt places oxysterols receptor LXR-alpha in the nucleus and cytoplasm. Tissue expression noted by UniProt (human): Visceral organs specific expression.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
Yao-Tsung Yeh et al. (2026) 3′-Hydroxypterostilbene Alleviates Obesity and Lipoprotein Metabolism Dysregulation by Reshaping Gut Microbiota in High-Fat Diet-Induced Obese Mice. Journal of Agricultural and Food Chemistry. 10.1021/acs.jafc.5c14405
