| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Oligodendrocyte-myelin glycoprotein;OMG;OMGP; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of human OMG, different from the related mouse sequence by two amino acids. |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Overview
This antibody is intended for detection of OMG (Oligodendrocyte-myelin glycoprotein) in biological samples using common immunoassay formats. It is typically selected based on target identity, species reactivity, clonality/clone information, and detection modality.
Vendor notes: Boster Bio Anti-Oligodendrocyte myelin glycoprotein/OMG Antibody Picoband® catalog # PB9730. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key elements and design rationale
- Antibody format: Rabbit Polyclonal Rabbit IgG
- Immunogen / epitope context: A synthetic peptide corresponding to a sequence at the N-terminus of human OMG, different from the related mouse sequence by two amino acids.
- Molecular weight context: reported MW: 50 kDa; calculated MW: 49608 MW
- Reactivity: Human,Mouse,Rat
- Applications: WB
As a polyclonal antibody, the reagent recognizes multiple epitopes on the target, which can improve detection robustness but may increase sensitivity to sample-dependent epitope changes.
Biological background
Oligodendrocyte-myelin glycoprotein; Oligodendrocyte-myelin glycoprotein. Oligodendrocyte-myelin glycoprotein is a protein that in humans is encoded by the OMG gene. This gene is mapped to 17q11-q12. OMG, like neurofibromin (NF1), has growth suppressive effects and downregulates mitogenic signaling pathways closely related to those influenced by neurofibromin. Overexpression of OMG alters mitogenic signaling in fibroblasts. Cells overexpressing OMG grow more slowly in serum compared to controls and show a partial G1 block upon cell cycle analysis. Functional note: Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system. Reported localization: Cell membrane; Lipid-anchor, GPI-anchor. Expression/tissue context: Oligodendrocytes and myelin of the central nervous system.
Research relevance and current trends
- Cell Adhesion Proteins: Researchers commonly examine how OMG (Oligodendrocyte-myelin glycoprotein) relates to this theme using model systems and orthogonal readouts.
- Cell Type Marker: Researchers commonly examine how OMG (Oligodendrocyte-myelin glycoprotein) relates to this theme using model systems and orthogonal readouts.
- Membrane Proteins: Researchers commonly examine how OMG (Oligodendrocyte-myelin glycoprotein) relates to this theme using model systems and orthogonal readouts.
Common research applications
- Western blotting: compare relative OMG (Oligodendrocyte-myelin glycoprotein) levels across conditions; band patterns may reflect isoforms and processing.
Notes for experimental interpretation
- Specificity notes: No cross reactivity with other proteins.
- Cross-reactivity: No cross-reactivity with other proteins.
- Isoforms and PTMs: Apparent size and signal patterns can differ across splice isoforms, proteolytic processing, and post-translational modifications.
- Controls: Include an isotype control (as relevant), no-primary control for imaging, and orthogonal validation such as KD/KO samples when available.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
