| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Cadherin 3, type 1, P-cadherin (Placental) ;Protein Cdh3 ;Cdh3 ;rCG_51631 ; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Gene ID | |
| Host | |
| Immunogen | Synthetic peptide corresponding to the C-terminal amino acids of chicken N-Cadherin with an extra N-terminal lysine residue (24 amino acids) coupled to KLH. |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Overview
Anti-P-Cadherin-3 CDH3-Antibody (Monoclonal, CH-19) is an antibody targeting CDH1; CDH2; CDH3. Common applications include WB, IHC. Key specifications include host: Mouse; clonality: Monoclonal; clone: Clone: CH-19; isotype: Mouse IgG1; reactivity: Chicken,Human,Mouse,Rabbit,Rat,Snake; observed MW: 53 kDa; calculated MW: 90415 MW.
Boster Bio Anti-P-Cadherin-3 CDH3-Antibody (Monoclonal, CH-19) catalog # MA1079. Tested in IHC, WB applications. This antibody reacts with Chicken, Human, Mouse, Rabbit, Rat, Snake.
Key elements and design rationale
- Target: CDH1; CDH2; CDH3 — cadherin 1, type 1, E-cadherin(epithelial); cadherin 2, type 1, N-cadherin(neuronal); cadherin 3, type 1, P-cadherin(placental)
- Antibody format: Host: Mouse; Clonality: Monoclonal; Clone: Clone: CH-19; Isotype: Mouse IgG1
- Species reactivity: Chicken,Human,Mouse,Rabbit,Rat,Snake
- Molecular weight guidance: Observed: 53 kDa; Calculated: 90415 MW
Specificity note: No cross reactivity with other proteins.
Biological background
Protein function (datasheet): Cadherins are calcium-dependent cell adhesion proteins. .
Scientific background (datasheet): Cadherins are calcium-dependent cell-cell adhesion molecules that mediate cell-cell binding in a homophilic manner. They play an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. Cadherin expression is regulated spatially as well as temporally. Cadherins are though to play an important role in development and maintenance of tissues through selective cell-cell adhesion activity and may be involved also in the invasion and metastasis of malignant tumors. Cadherin regulates dendritic spine morphogenesis. A cadherin gene cluster is mapped to a region of chromosome 5 subject to frequent allelic loss in carcinoma.
Cellular localization (datasheet): CDH1: Cell junction. Cell membrane; Single-passtype I membrane protein. Endosome. Golgi apparatus, trans-Golginetwork. Note: Colocalizes with DLGAP5 at sites of cell-cellcontact in intestinal epithelial cells. Anchored to actinmicrofilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calciuminflux, results in translocation from sites of cell-cell contactto the cytoplasm. Colocalizes with RAB11A endosomes during itstransport from the Golgi apparatus to the plasma membrane.|Cdh1: Cell junction. Cell membrane; Single-passtype I membrane protein. Endosome Golgi apparatus,trans-Golgi network Note: Colocalizes with DLGAP5 atsites of cell-cell contact in intestinal epithelial cells.Anchored to actin microfilaments through association with alpha-,beta- and gamma-catenin. Sequential proteolysis induced byapoptosis or calcium influx, results in translocation from sitesof cell-cell contact to the cytoplasm. Colocalizes with RAB11Aendosomes during its transport from the Golgi apparatus to theplasma membrane (By similarity). |Cdh1: Cell junction. Cell membrane; Single-passtype I membrane protein. Endosome Golgi apparatus,trans-Golgi network Note: Colocalizes with DLGAP5 atsites of cell-cell contact in intestinal epithelial cells.Anchored to actin microfilaments through association with alpha-,beta- and gamma-catenin. Sequential proteolysis induced byapoptosis or calcium influx, results in translocation from sitesof cell-cell contact to the cytoplasm. Colocalizes with RAB11Aendosomes during its transport from the Golgi apparatus to theplasma membrane (By similarity). |CDH2: Cell membrane; Single-pass type I membraneprotein.|Cdh2: Cell membrane; Single-pass type I membraneprotein.|Cdh2: Cell membrane |CDH3: Cell membrane; Single-pass type I membraneprotein.|Cdh3: Cell membrane; Single-pass type I membraneprotein.
Tissue details (datasheet): CDH1: Non-neural epithelial tissues.
Sequence similarities (datasheet): Contains 5 cadherin domains.
Research relevance and current trends
- Commonly studied in contexts related to Cadherins,Cell Adhesion,Cytoskeleton/ECM,Neuroscience,Sensory System,Signal Transduction,Visual System.
- Supports comparative expression analysis across conditions, genotypes, or treatments when paired with appropriate controls.
- Useful for confirming target presence and subcellular distribution using orthogonal readouts (e.g., microscopy vs. immunoblotting).
Common research applications
- Western blot (WB): Compare relative target abundance and apparent size/isoforms across samples; interpret bands in light of expected MW and potential PTMs.
- Immunohistochemistry (IHC): Assess tissue distribution and cell-type patterns; interpret staining with appropriate negative controls and antigen context.
Notes for experimental interpretation
- Consider isoforms, post-translational modifications, and processing that can shift apparent molecular weight or localization.
- Cross-reactivity (datasheet): No cross-reactivity with other proteins
- Use appropriate positive and negative controls (e.g., KO/KD, blocking peptide, or isotype controls) to support specificity interpretation.
As a monoclonal antibody, this reagent is expected to recognize a defined epitope, which can support consistency across lots when epitope accessibility is preserved.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
