| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Cyclin-dependent kinase 4 inhibitor D;p19-INK4d;Cdkn2d; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Gene ID | |
| Host | |
| Immunogen | Recombinant human p19INK4d. |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Overview
Anti-p19INK4d Cdkn2d Antibody (Monoclonal, DCS-100) is an antibody targeting CDKN2D. Common applications include WB, IHC, ICC. Key specifications include host: Mouse; clonality: Monoclonal; clone: Clone: DCS-100; isotype: Mouse IgG1; reactivity: Human; observed MW: 18 kDa; calculated MW: 17809 MW.
Boster Bio Anti-p19INK4d Cdkn2d Antibody (Monoclonal, DCS-100) catalog # MA1075. Tested in IHC, ICC, WB applications. This antibody reacts with Human.
Key elements and design rationale
- Target: CDKN2D — Cyclin-dependent kinase 4 inhibitor D
- Antibody format: Host: Mouse; Clonality: Monoclonal; Clone: Clone: DCS-100; Isotype: Mouse IgG1
- Species reactivity: Human
- Molecular weight guidance: Observed: 18 kDa; Calculated: 17809 MW
Specificity note: No cross reactivity with other proteins.
Biological background
Protein function (datasheet): Interacts strongly with CDK4 and CDK6 and inhibits them. .
Scientific background (datasheet): Cyclins are important in regulating the cell cycle through their formation of enzymatic complexes with various cyclin-dependent kinases. P19 (INK4d) also kowns as cyclin-dependent kinase inhibitor 2D, is one of the novel members of the mouse INK4 gene family. Okuda et al. (1995) described the cloning of the human INK4d gene (CDKN2D). The predicted 166-amino acid protein is 86% identical to the mouse protein and about 45% identical to other human INK4 family members.
Cellular localization (datasheet): Nucleus . Cytoplasm .
Tissue details (datasheet): Expressed in spleen, liver and lung. Not detected in kidney, colon, stomach or brain. .
Sequence similarities (datasheet): Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
Research relevance and current trends
- Commonly studied in contexts related to Cancer,Cell Biology,Cell Cycle,Cell Cycle Inhibitors,Epigenetics and Nuclear Signaling,Oncoproteins/Suppressors,Tumor Suppressors.
- Supports comparative expression analysis across conditions, genotypes, or treatments when paired with appropriate controls.
- Useful for confirming target presence and subcellular distribution using orthogonal readouts (e.g., microscopy vs. immunoblotting).
Common research applications
- Western blot (WB): Compare relative target abundance and apparent size/isoforms across samples; interpret bands in light of expected MW and potential PTMs.
- Immunohistochemistry (IHC): Assess tissue distribution and cell-type patterns; interpret staining with appropriate negative controls and antigen context.
- Immunofluorescence / ICC: Visualize subcellular localization and co-localization patterns; consider fixation/permeabilization compatibility and controls.
Notes for experimental interpretation
- Consider isoforms, post-translational modifications, and processing that can shift apparent molecular weight or localization.
- Cross-reactivity (datasheet): No cross-reactivity with other proteins
- Use appropriate positive and negative controls (e.g., KO/KD, blocking peptide, or isotype controls) to support specificity interpretation.
As a monoclonal antibody, this reagent is expected to recognize a defined epitope, which can support consistency across lots when epitope accessibility is preserved.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
