| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Glycogen [starch] synthase, muscle;2.4.1.11;GYS1;GYS; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | A synthesized peptide derived from human Phospho-Glycogen synthase 1 (S641) |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Target | |
| UniProt # |
Overview
Anti-Phospho-Glycogen synthase 1 (S641) GYS1 Rabbit Monoclonal Antibody is an antibody targeting GYS1. Common applications include WB, IHC, ICC, IF, IP. Key specifications include host: Rabbit; clonality: Monoclonal; clone: Clone: DCH-7; isotype: Rabbit IgG; reactivity: Human,Mouse; observed MW: 40 kDa; calculated MW: 83786 MW.
Boster Bio Anti-Phospho-Glycogen synthase 1 (S641) GYS1 Rabbit Monoclonal Antibody catalog # P03512-2. Tested in WB, IHC, ICC/IF, IP applications. This antibody reacts with Human, Mouse.
Key elements and design rationale
- Target: GYS1 — Glycogen [starch] synthase, muscle
- Antibody format: Host: Rabbit; Clonality: Monoclonal; Clone: Clone: DCH-7; Isotype: Rabbit IgG
- Species reactivity: Human,Mouse
- Molecular weight guidance: Observed: 40 kDa; Calculated: 83786 MW
- Phospho site(s): S641
Biological background
Protein function (datasheet): Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan.
Cellular localization (datasheet): Cytoplasm . Cell membrane ; Peripheral membrane protein . Membrane raft . Cytoplasm, cytoskeleton . Membrane ; Peripheral membrane protein . Translocates to the plasma membrane when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Translocates from the cytoplasm to membrane ruffles in a FCGR3/CD16-dependent manner. Colocalizes with FC-gamma-RIIB receptor (FCGR2B) or FCGR3/CD16 at membrane ruffles. Tyrosine phosphorylation may also participate in membrane localization. .
Tissue details (datasheet): Specifically expressed in immune and hematopoietic cells. Expressed in bone marrow and blood cells. Levels vary considerably within this compartment. Present in at least 74% of immature CD34+ cells, whereas within the more mature population of CD33+ cells, it is present in only 10% of cells. Present in the majority of T-cells, while it is present in a minority of B-cells (at protein level). .
Research relevance and current trends
- Commonly studied in contexts related to Atherosclerosis,Cancer,Cancer Metabolism,Carbohydrate Metabolism,Cardiovascular,Diabetes,Diabetes-associated,Energy Metabolism,Energy Transfer Pathways,Heart Disease,Metabolic Signaling Pathway,Metabolic Signaling Pathways,Metabolism,Metabolism Of Carbohydrates,Obesity,Pathways and Processes,Signal Transduction.
- Supports comparative expression analysis across conditions, genotypes, or treatments when paired with appropriate controls.
- Useful for confirming target presence and subcellular distribution using orthogonal readouts (e.g., microscopy vs. immunoblotting).
Common research applications
- Western blot (WB): Compare relative target abundance and apparent size/isoforms across samples; interpret bands in light of expected MW and potential PTMs.
- Immunohistochemistry (IHC): Assess tissue distribution and cell-type patterns; interpret staining with appropriate negative controls and antigen context.
- Immunofluorescence / ICC: Visualize subcellular localization and co-localization patterns; consider fixation/permeabilization compatibility and controls.
Notes for experimental interpretation
- Consider isoforms, post-translational modifications, and processing that can shift apparent molecular weight or localization.
- Use appropriate positive and negative controls (e.g., KO/KD, blocking peptide, or isotype controls) to support specificity interpretation.
As a monoclonal antibody, this reagent is expected to recognize a defined epitope, which can support consistency across lots when epitope accessibility is preserved.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
