| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Prostaglandin E2 receptor EP2 subtype;PGE receptor EP2 subtype;PGE2 receptor EP2 subtype;Prostanoid EP2 receptor;PTGER2; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human PTGER2, different from the related mouse sequence by four amino acids, and from the related rat sequence by three amino acids. |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Overview
This antibody is intended for detection of PTGER2 (Prostaglandin E2 receptor EP2 subtype) in biological samples using common immunoassay formats. It is typically selected based on target identity, species reactivity, clonality/clone information, and detection modality.
Vendor notes: Boster Bio Anti-Prostaglandin E Receptor EP2/PTGER2 Antibody Picoband® catalog # PB9386. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key elements and design rationale
- Antibody format: Rabbit Polyclonal Rabbit IgG
- Immunogen / epitope context: A synthetic peptide corresponding to a sequence at the C-terminus of human PTGER2, different from the related mouse sequence by four amino acids, and from the related rat sequence by three amino acids.
- Molecular weight context: reported MW: 40 kDa; calculated MW: 39761 MW
- Reactivity: Human
- Applications: WB
As a polyclonal antibody, the reagent recognizes multiple epitopes on the target, which can improve detection robustness but may increase sensitivity to sample-dependent epitope changes.
Biological background
Prostaglandin E2 receptor EP2 subtype; Prostaglandin E2 receptor EP2 subtype. Prostaglandin E2 receptor (53kDa), also known as EP2, is aprostaglandin receptor for prostaglandin E2. It is encoded by the human gene PTGER2. It may be associated with aspirin-induced asthma. PTGER2 is mapped to chromosome 14q22. This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. Functional note: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G (s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle. Reported localization: Cell membrane; Multi-pass membrane protein. Expression/tissue context: Placenta and lung.
Research relevance and current trends
- G Protein Signaling: Researchers commonly examine how PTGER2 (Prostaglandin E2 receptor EP2 subtype) relates to this theme using model systems and orthogonal readouts.
- Lipid Signaling: Researchers commonly examine how PTGER2 (Prostaglandin E2 receptor EP2 subtype) relates to this theme using model systems and orthogonal readouts.
- Signal Transduction: Researchers commonly examine how PTGER2 (Prostaglandin E2 receptor EP2 subtype) relates to this theme using model systems and orthogonal readouts.
Common research applications
- Western blotting: compare relative PTGER2 (Prostaglandin E2 receptor EP2 subtype) levels across conditions; band patterns may reflect isoforms and processing.
Notes for experimental interpretation
- Specificity notes: No cross reactivity with other proteins.
- Cross-reactivity: No cross-reactivity with other proteins.
- Family / similarity context: Belongs to the G-protein coupled receptor 1 family.
- Isoforms and PTMs: Apparent size and signal patterns can differ across splice isoforms, proteolytic processing, and post-translational modifications.
- Controls: Include an isotype control (as relevant), no-primary control for imaging, and orthogonal validation such as KD/KO samples when available.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
