| Field | Specification |
|---|---|
| Target | |
| Alternative names | Retinoic acid receptor alpha;RAR-alpha;Nuclear receptor subfamily 1 group B member 1;RARA;NR1B1; |
| Gene ID | |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human Retinoic Acid Receptor alpha |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone GBC-18 is a rabbit monoclonal antibody that recognizes retinoic acid receptor alpha (gene RARA) in human and mouse samples and is validated for Western blot and flow cytometry. The predicted molecular weight is 50.8 kDa, and the supplier reports an observed band at about 55 kDa.
Retinoic acid receptor alpha (RARα, RARA) is a nuclear receptor that pairs with RXR and binds retinoic acid response elements in DNA. Without ligand it recruits corepressors and keeps target genes silent; binding of all-trans or 9-cis retinoic acid swaps these for coactivators and switches genes on. RARA is studied in development, spermatogenesis and myeloid differentiation, and its fusion with PML underlies acute promyelocytic leukemia.
| Target | Retinoic acid receptor alpha (gene RARA; UniProt P10276, human) |
|---|---|
| Clone | GBC-18 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / Rabbit IgG |
| Reactivity | Human, Mouse |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 50.8 kDa |
| Observed MW | 55 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|---|
| Flow cytometry | 1:20 |
Immunogen
Synthetic peptide based on the sequence of human retinoic Acid Receptor alpha.
Reactivity Notes
The supplier lists reactivity with human and mouse. UniProt places retinoic acid receptor alpha in the nucleus and cytoplasm. Tissue expression noted by UniProt (human): Expressed in monocytes.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
