| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Protein S100-A11;Calgizzarin;Metastatic lymph node gene 70 protein;MLN 70;Protein S100-C;S100 calcium-binding protein A11;Protein S100-A11, N-terminally processed;S100A11;MLN70, S100C; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | E. coli-derived human S100A11 recombinant protein (Position: A2-T105). Human S100A11 shares 86.7% amino acid (aa) sequence identity with both mouse and rat S100A11. |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Overview
This antibody is intended for detection of S100A11 (Protein S100-A11) in biological samples using common immunoassay formats. It is typically selected based on target identity, species reactivity, clonality/clone information, and detection modality.
Vendor notes: Boster Bio Anti-S100A11 Antibody Picoband® catalog # PB9818. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key elements and design rationale
- Antibody format: Rabbit Polyclonal Rabbit IgG
- Immunogen / epitope context: E. coli-derived human S100A11 recombinant protein (Position: A2-T105). Human S100A11 shares 86.7% amino acid (aa) sequence identity with both mouse and rat S100A11. (reported region: A2-T105).
- Molecular weight context: reported MW: 15 kDa; calculated MW: 11740 MW
- Reactivity: Human
- Applications: WB
As a polyclonal antibody, the reagent recognizes multiple epitopes on the target, which can improve detection robustness but may increase sensitivity to sample-dependent epitope changes.
Biological background
Protein S100-A11; Protein S100-A11. S100 calcium-binding protein A11 (S100A11) is a protein that in humans is encoded by the S100A11 gene. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. And S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Functional note: Facilitates the differentiation and the cornification of keratinocytes. . Reported localization: Cytoplasm . Nucleus . Expression/tissue context: Overexpressed in bladder cancer cells (PubMed:17409436). .
Research relevance and current trends
- Calcium Binding Proteins: Researchers commonly examine how S100A11 (Protein S100-A11) relates to this theme using model systems and orthogonal readouts.
- Calcium Signaling: Researchers commonly examine how S100A11 (Protein S100-A11) relates to this theme using model systems and orthogonal readouts.
- Cell Cycle: Researchers commonly examine how S100A11 (Protein S100-A11) relates to this theme using model systems and orthogonal readouts.
Common research applications
- Western blotting: compare relative S100A11 (Protein S100-A11) levels across conditions; band patterns may reflect isoforms and processing.
Notes for experimental interpretation
- Specificity notes: No cross reactivity with other proteins.
- Cross-reactivity: No cross-reactivity with other proteins.
- Isoforms and PTMs: Apparent size and signal patterns can differ across splice isoforms, proteolytic processing, and post-translational modifications.
- Controls: Include an isotype control (as relevant), no-primary control for imaging, and orthogonal validation such as KD/KO samples when available.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
