| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Histone-lysine N-methyltransferase SETD7;2.1.1.43;Histone H3-K4 methyltransferase SETD7;H3-K4-HMTase SETD7;Lysine N-methyltransferase 7;SET domain-containing protein 7;SET7/9;SETD7;KIAA1717, KMT7, SET7, SET9; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Gene ID | |
| Host | |
| Immunogen | A synthesized peptide derived from human SETD7 |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Overview
Anti-SETD7/Set7 Rabbit Monoclonal Antibody is an antibody targeting SETD7. Common applications include WB, IP. Key specifications include host: Rabbit; clonality: Monoclonal; clone: Clone: ABA-19; isotype: Rabbit IgG; reactivity: Human,Mouse,Rat; observed MW: 48 kDa; calculated MW: 40721 MW.
Boster Bio Anti-SETD7/Set7 Rabbit Monoclonal Antibody catalog # M02793. Tested in WB, IP applications. This antibody reacts with Human, Mouse, Rat.
Key elements and design rationale
- Target: SETD7 — Histone-lysine N-methyltransferase SETD7
- Antibody format: Host: Rabbit; Clonality: Monoclonal; Clone: Clone: ABA-19; Isotype: Rabbit IgG
- Species reactivity: Human,Mouse,Rat
- Molecular weight guidance: Observed: 48 kDa; Calculated: 40721 MW
Biological background
Protein function (datasheet): Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. .
Cellular localization (datasheet): Nucleus. Chromosome .
Tissue details (datasheet): Widely expressed. Expressed in pancreatic islets.
Research relevance and current trends
- Commonly studied in contexts related to 2339,Chromatin Modifying Enzymes,Epigenetics and Nuclear Signaling,Methylation.
- Supports comparative expression analysis across conditions, genotypes, or treatments when paired with appropriate controls.
- Useful for confirming target presence and subcellular distribution using orthogonal readouts (e.g., microscopy vs. immunoblotting).
Common research applications
- Western blot (WB): Compare relative target abundance and apparent size/isoforms across samples; interpret bands in light of expected MW and potential PTMs.
Notes for experimental interpretation
- Consider isoforms, post-translational modifications, and processing that can shift apparent molecular weight or localization.
- Use appropriate positive and negative controls (e.g., KO/KD, blocking peptide, or isotype controls) to support specificity interpretation.
As a monoclonal antibody, this reagent is expected to recognize a defined epitope, which can support consistency across lots when epitope accessibility is preserved.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
