Anti-SHP2 PTPN11 Rabbit Monoclonal Antibody

Overview

Anti-SHP2 PTPN11 Rabbit Monoclonal Antibody is an antibody targeting PTPN11. Common applications include WB, IHC, IP. Key specifications include host: Rabbit; clonality: Monoclonal; clone: Clone: GBO-16; isotype: Rabbit IgG; reactivity: Human,Mouse,Rat; observed MW: 68 kDa; calculated MW: 68 kDa.

Boster Bio Anti-SHP2 PTPN11 Rabbit Monoclonal Antibody catalog # M00150-1. Tested in WB, IHC, IP applications. This antibody reacts with Human, Mouse, Rat.

Key elements and design rationale

• Target: PTPN11 — Tyrosine-protein phosphatase non-receptor type 11
• Antibody format: Host: Rabbit; Clonality: Monoclonal; Clone: Clone: GBO-16; Isotype: Rabbit IgG
• Species reactivity: Human,Mouse,Rat
• Molecular weight guidance: Observed: 68 kDa; Calculated: 68 kDa

Biological background

Protein function (datasheet): Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. .

Cellular localization (datasheet): Cytoplasm.

Tissue details (datasheet): Widely expressed, with highest levels in heart, brain, and skeletal muscle. .

Research relevance and current trends

• Commonly studied in contexts related to Neuroscience,Protein Phosphorylation,Sensory System,Signal Transduction,Tyrosine Phosphatases.
• Supports comparative expression analysis across conditions, genotypes, or treatments when paired with appropriate controls.
• Useful for confirming target presence and subcellular distribution using orthogonal readouts (e.g., microscopy vs. immunoblotting).

Common research applications

• Western blot (WB): Compare relative target abundance and apparent size/isoforms across samples; interpret bands in light of expected MW and potential PTMs.
• Immunohistochemistry (IHC): Assess tissue distribution and cell-type patterns; interpret staining with appropriate negative controls and antigen context.

Notes for experimental interpretation

• Consider isoforms, post-translational modifications, and processing that can shift apparent molecular weight or localization.
• Use appropriate positive and negative controls (e.g., KO/KD, blocking peptide, or isotype controls) to support specificity interpretation.

As a monoclonal antibody, this reagent is expected to recognize a defined epitope, which can support consistency across lots when epitope accessibility is preserved.

Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.