Anti-TAB2 Antibody Picoband®

Overview

Anti-TAB2 Antibody Picoband® is an antibody for TAB2 detection raised in Rabbit (Polyclonal, Rabbit IgG), with reported reactivity: Human. Commonly used in WB, IHC, Flow Cytometry, ELISA workflows.

Key elements and design rationale

• Target: TAB2 (TNF receptor superfamily member 4); UniProt: Q9NYJ8
• Antibody format: Rabbit, Polyclonal, Rabbit IgG
• Molecular weight: 76 kDa
• Applications: WB, IHC, Flow Cytometry, ELISA

Vendor description (summary): Boster Bio Anti-TAB2 Antibody Picoband® catalog # A02499-1.

Biological background

Biological context: Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity). .

Expression and localization notes: cellular localization: Membrane; Single-pass type I membrane protein..

Common research applications

• Western blotting (WB): Compare TAB2 levels across samples and conditions using appropriate loading and biological controls.
• Immunohistochemistry (IHC): Evaluate spatial distribution of TAB2 in tissue sections, considering fixation and antigen retrieval effects.
• Flow cytometry: Quantify TAB2-positive populations in single-cell suspensions with appropriate gating and controls.
• ELISA: Use antibody-based detection formats to assess antigen presence or binding in plate-based assays.

Notes for experimental interpretation

• Account for isoforms, post-translational modifications, and sample-specific processing that can shift apparent molecular weight or epitope accessibility.
• Use positive/negative biological controls where possible (e.g., known-expressing cells/tissues, knockdown/knockout models) and include appropriate secondary-only/isotype controls for imaging workflows.

Additional product notes (from provided fields)

• Background: Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, also known as TAB2, is an enzyme that in humans is encoded by the MAP3K7IP2 gene. The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. TAB2 functionally links TAK1 to TRAF6. What's more, TAB2 can act as a sensor for inflammatory signals by serving as a molecular beacon for recruitment of MEKK1 (MAP3K1), which in turn mediated dismissal of the NCOR/HDAC complex and permitted derepression of AR and estrogen receptor target genes.
• Cross reactivity: No cross-reactivity with other proteins.
• Cellular localization: Membrane; Single-pass type I membrane protein.
• Research category: Adaptive Immunity,Autoimmune,B Cells,Cytokines,Hematopoietic Progenitors,Immune System Diseases,Immunology,Innate Immunity,Lymphoid,Stem Cells,T Cells,T Lymphocytic Lineage,TNF Superfamily

Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.