Anti-TCPTP/PTPN2 Antibody Picoband®

Overview

Anti-TCPTP/PTPN2 Antibody Picoband® is an antibody for PTPN2 detection raised in Rabbit (Polyclonal, Rabbit IgG), with reported reactivity: Human. Commonly used in WB, IHC, Flow Cytometry, ELISA workflows.

Key elements and design rationale

• Target: PTPN2 (Multidrug resistance-associated protein 4); UniProt: P17706
• Antibody format: Rabbit, Polyclonal, Rabbit IgG
• Molecular weight: 48 kDa, calculated 149527 MW
• Applications: WB, IHC, Flow Cytometry, ELISA

Vendor description (summary): Boster Bio Anti-TCPTP/PTPN2 Antibody Picoband® catalog # A01597-1.

Biological background

Biological context: May be an organic anion pump relevant to cellular detoxification.

Expression and localization notes: cellular localization: Membrane; Multi-pass membrane protein., tissue context: Widely expressed, with particularly high levels in prostate, but is barely detectable in liver..

Common research applications

• Western blotting (WB): Compare PTPN2 levels across samples and conditions using appropriate loading and biological controls.
• Immunohistochemistry (IHC): Evaluate spatial distribution of PTPN2 in tissue sections, considering fixation and antigen retrieval effects.
• Flow cytometry: Quantify PTPN2-positive populations in single-cell suspensions with appropriate gating and controls.
• ELISA: Use antibody-based detection formats to assess antigen presence or binding in plate-based assays.

Notes for experimental interpretation

• Account for isoforms, post-translational modifications, and sample-specific processing that can shift apparent molecular weight or epitope accessibility.
• Use positive/negative biological controls where possible (e.g., known-expressing cells/tissues, knockdown/knockout models) and include appropriate secondary-only/isotype controls for imaging workflows.

Additional product notes (from provided fields)

• Background: TCPTP is also called as PTPN2. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported.
• Cross reactivity: No cross-reactivity with other proteins.
• Cellular localization: Membrane; Multi-pass membrane protein.
• Tissue details: Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.
• Research category: ATPases,Cancer,Channels,Drug Metabolism,Metabolism,Plasma Membrane,Signal Transduction

Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.