| Field | Specification |
|---|---|
| Target | |
| Alternative names | Short transient receptor potential channel 7;TrpC7;Transient receptor protein 7;TRP-7;hTRP7;TRPC7;TRP7; |
| UniProt # | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | E.coli-derived human TRP 7 recombinant protein (Position: K716-I862). Human TRP 7 shares 95% amino acid (aa) sequence identity with mouse TRP 7. |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Lyophilized |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
This rabbit polyclonal antibody targets short transient receptor potential channel 7 (gene TRPC7) in human and mouse samples and is validated for Western blot. The predicted molecular weight is 99.6 kDa, and the supplier reports an observed band at about 99 kDa.
TRPC7 is a canonical transient receptor potential channel closely related to TRPC3 and TRPC6. It conducts calcium and other cations, can be activated by diacylglycerol after phospholipase C signaling, and may also respond to store depletion; together with TRPC6 it is thought to contribute to light responses of melanopsin-expressing retinal ganglion cells.
| Target | Short transient receptor potential channel 7 (gene TRPC7; UniProt Q9HCX4, human) |
|---|---|
| Host / Clonality / Isotype | Rabbit / Polyclonal / Rabbit IgG |
| Reactivity | Human, Mouse |
| Form | Lyophilized |
| Formulation | Per vial: 0.9 mg NaCl; 0.2 mg Na2HPO4; 0.05 mg NaN3; plus stabilizers |
| Calculated MW | 99.6 kDa |
| Observed MW | 99 kDa |
| Storage | As supplied: −20 °C for up to 12 months from receipt. After reconstitution: 4 °C for up to 1 month, or aliquot and keep at −20 °C for up to 6 months. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 0.1–0.5 µg/mL (Human, Mouse) |
|---|
Samples with a confirmed band (WB): mouse brain tissue, A549 cells, COLO320 cells, SKOV cells.
Recommended loading (WB): 20–40 µg of total protein per lane.
Immunogen
Recombinant human TRP 7 fragment (Lys716–Ile862), expressed in E. coli. Sequence identity with the mouse ortholog: 95%.
Reactivity Notes
The supplier lists reactivity with human and mouse. UniProt places short transient receptor potential channel 7 in the cell membrane and nucleus envelope. The samples tested by the supplier (listed above) are a practical starting point for positive controls.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
Yuan Wang et al. (2016) TRPC1/TRPC3 channels mediate lysophosphatidylcholine-induced apoptosis in cultured human coronary artery smooth muscles cells. Oncotarget. 10.18632/oncotarget.10853