| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Tumor necrosis factor-inducible gene 6 protein;Hyaluronate-binding protein;TNF-stimulated gene 6 protein;TSG-6;Tumor necrosis factor alpha-induced protein 6;TNF alpha-induced protein 6;TNFAIP6;TSG6; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of human TSG6, different from the related mouse sequence by two amino acids. |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Overview
This antibody is intended for detection of TNFAIP6 (Tumor necrosis factor-inducible gene 6 protein) in biological samples using common immunoassay formats. It is typically selected based on target identity, species reactivity, clonality/clone information, and detection modality.
Vendor notes: Boster Bio Anti-TSG6/TNFAIP6 Antibody Picoband® catalog # A03433-1. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key elements and design rationale
- Antibody format: Rabbit Polyclonal Rabbit IgG
- Immunogen / epitope context: A synthetic peptide corresponding to a sequence at the N-terminus of human TSG6, different from the related mouse sequence by two amino acids.
- Molecular weight context: reported MW: 31 kDa.; calculated MW: 31203 MW
- Reactivity: Human,Rat
- Applications: WB
As a polyclonal antibody, the reagent recognizes multiple epitopes on the target, which can improve detection robustness but may increase sensitivity to sample-dependent epitope changes.
Biological background
Tumor necrosis factor-inducible gene 6 protein; Tumor necrosis factor-inducible gene 6 protein. Tumor necrosis factor-inducible gene 6 protein, also known as TSG-6, is a protein that in humans is encoded by the TNFAIP6 gene. The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis. Functional note: Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis. Reported localization: Late endosome membrane. Peripheral membrane protein. Prevacuolar compartment membrane. Expression/tissue context: Found in the synovial fluid of patients with rheumatoid arthritis. .
Research relevance and current trends
- Cancer: Researchers commonly examine how TNFAIP6 (Tumor necrosis factor-inducible gene 6 protein) relates to this theme using model systems and orthogonal readouts.
- Cytoskeleton/ECM: Researchers commonly examine how TNFAIP6 (Tumor necrosis factor-inducible gene 6 protein) relates to this theme using model systems and orthogonal readouts.
- ECM Proteins: Researchers commonly examine how TNFAIP6 (Tumor necrosis factor-inducible gene 6 protein) relates to this theme using model systems and orthogonal readouts.
Common research applications
- Western blotting: compare relative TNFAIP6 (Tumor necrosis factor-inducible gene 6 protein) levels across conditions; band patterns may reflect isoforms and processing.
Notes for experimental interpretation
- Specificity notes: No cross reactivity with other proteins.
- Cross-reactivity: No cross-reactivity with other proteins.
- Isoforms and PTMs: Apparent size and signal patterns can differ across splice isoforms, proteolytic processing, and post-translational modifications.
- Controls: Include an isotype control (as relevant), no-primary control for imaging, and orthogonal validation such as KD/KO samples when available.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
