| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Tyrosine 3-monooxygenase;1.14.16.2;Tyrosine 3-hydroxylase;TH;Th; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Gene ID | |
| Host | |
| Immunogen | Rat tyrosine hydroxylase (TH). |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Overview
Anti-Tyrosine Hydroxylase Antibody (Monoclonal, TH-16) is an antibody targeting TH. Common applications include WB, IHC. Key specifications include host: Mouse; clonality: Monoclonal; clone: Clone: TH-16; isotype: Mouse IgG1; reactivity: Human,Mouse,Rabbit,Rat; observed MW: 59 kDa; calculated MW: 55966 MW.
Boster Bio Anti-Tyrosine Hydroxylase Antibody (Monoclonal, TH-16) catalog # MA1100. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rabbit, Rat.
Key elements and design rationale
- Target: TH — Tyrosine 3-monooxygenase
- Antibody format: Host: Mouse; Clonality: Monoclonal; Clone: Clone: TH-16; Isotype: Mouse IgG1
- Species reactivity: Human,Mouse,Rabbit,Rat
- Molecular weight guidance: Observed: 59 kDa; Calculated: 55966 MW
Specificity note: No cross reactivity with other proteins.
Biological background
Protein function (datasheet): Plays an important role in the physiology of adrenergic neurons.
Scientific background (datasheet): Tyrosine hydroxylase is involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Human TH gene contains 13 primary exons and spans approximately 8 kb. TH is in the 11p15.5 region.
Cellular localization (datasheet): Cytoplasm, cytoskeleton.
Tissue details (datasheet): TH: Mainly expressed in the brain and adrenalglands.
Sequence similarities (datasheet): Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Research relevance and current trends
- Commonly studied in contexts related to Cancer,Cancer Metabolism,Cell Type Marker,Endocrine Metabolism,Hormone Biosynthesis,Hypoxia,Metabolic Signaling Pathway,Metabolism,Metabolism Processes,Neuron Marker,Neuroscience,Neurotransmitter,Pathways and Processes,Response To Hypoxia.
- Supports comparative expression analysis across conditions, genotypes, or treatments when paired with appropriate controls.
- Useful for confirming target presence and subcellular distribution using orthogonal readouts (e.g., microscopy vs. immunoblotting).
Common research applications
- Western blot (WB): Compare relative target abundance and apparent size/isoforms across samples; interpret bands in light of expected MW and potential PTMs.
- Immunohistochemistry (IHC): Assess tissue distribution and cell-type patterns; interpret staining with appropriate negative controls and antigen context.
Notes for experimental interpretation
- Consider isoforms, post-translational modifications, and processing that can shift apparent molecular weight or localization.
- Cross-reactivity (datasheet): No cross-reactivity with other proteins
- Use appropriate positive and negative controls (e.g., KO/KD, blocking peptide, or isotype controls) to support specificity interpretation.
As a monoclonal antibody, this reagent is expected to recognize a defined epitope, which can support consistency across lots when epitope accessibility is preserved.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
