| Field | Specification |
|---|---|
| Target | |
| Alternative names | Tyrosine 3-monooxygenase;1.14.16.2;Tyrosine 3-hydroxylase;TH;Th; |
| Gene ID | |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | Rat tyrosine hydroxylase (TH). |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Lyophilized |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone TH-16 is a mouse monoclonal antibody that recognizes tyrosine 3-monooxygenase (gene Th) in human, mouse, rabbit and rat samples and is validated for Western blot and IHC.
Tyrosine hydroxylase (TH) converts L-tyrosine to L-DOPA using tetrahydrobiopterin and oxygen, the rate-limiting step in making dopamine, noradrenaline and adrenaline. It is expressed in catecholaminergic neurons and adrenal chromaffin cells, and its activity is tightly controlled by phosphorylation. TH is the standard marker for dopaminergic neurons and is central to research on Parkinson's disease and the stress response.
| Target | Tyrosine 3-monooxygenase (gene Th; UniProt P04177, rat) |
|---|---|
| Clone | TH-16 |
| Host / Clonality / Isotype | Mouse / Monoclonal / Mouse IgG1 |
| Reactivity | Human, Mouse, Rabbit, Rat |
| Purification | Ascites |
| Form | Lyophilized |
| Formulation | 1.2% sodium acetate; 0.01 mg NaN3; plus stabilizers |
| Reconstitution | 100 µg/mL after adding 1 mL PBS |
| Storage | As supplied: −20 °C for up to 12 months from receipt. After reconstitution: 4 °C for up to 1 month, or aliquot and keep at −20 °C for up to 6 months. Avoid repeated freeze–thaw cycles. |
Validated Applications
| IHC (paraffin sections) | 0.5–1 µg/mL (Human, Rat, Rabbit) |
|---|---|
| Western blot | 0.25–0.5 µg/mL (Human, Mouse, Rat, Rabbit) |
Conditions in the example images (IHC): heat-mediated antigen retrieval in citrate buffer (pH 6).
Immunogen
Rat tyrosine hydroxylase (TH).
Reactivity Notes
The supplier lists reactivity with human, mouse, rabbit and rat. UniProt places tyrosine 3-monooxygenase in the cytoplasm, nucleus and cell projection.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
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