| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | (3S,6S,9S,15aR)-9-[(2S)-2-Butanyl]-6-[(1-methoxy-1H-indol-3-yl)methyl]-3-(6-oxooctyl)octahydro-2H-pyrido[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10(3H,12H)-tetrone; Cyclo(N-O-methyl-L-tryptophanyl-L Lisoleucinyl-Dpipecolinyl-L-2-amino-8-oxodecanoyl) |
| Cas No. | |
| Form | White Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in 10 mg/ml DMSO or 100% Ethanol |
| Source | Synthetic |
| Storage |
Apicidin is a cyclopeptide inhibitor of histone deacetylases (HDACs), known for its ability to induce transcriptional activation and inhibit cell proliferation. While it has been primarily studied in oncology for its antiproliferative effects, Apicidin’s role in epigenetic modulation has implications for neuroscience. HDAC inhibitors like Apicidin are being explored for their potential to enhance synaptic plasticity, memory formation, and neuroprotection. By altering chromatin structure and gene expression, Apicidin may influence pathways involved in neurodegenerative diseases such as Alzheimer’s and Huntington’s. Its ability to decrease HIF1α protein levels and modulate transcriptional activity further supports its relevance in cellular stress responses, making it a candidate for broader neurological research.
Classification: Toxic. May be harmful or fatal if inhaled, swallowed, or absorbed through skin.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
Hazard Statements:
- H300+H310 – Fatal if swallowed or in contact with skin.
- H330 – Fatal if inhaled
Precautionary Statements:
- P260 – Do not breathe dust/fumes/gas/mist/vapours/spray
- P264- Wash hands thoroughly after handling
- P280 – Wear protective gloves/ Protective clothing
- P284 – Wear respiratory protection
- P302 + P350 – If on skin: Gently wash with plenty of soap and water.
- P310 – Immediately call a poison center or doctor/ physician
Apicidin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-346)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Han J.W., et al. (2000) Cancer Res. 60: 6068.
3. Kim S.H., et al. (2007) Oncol. Rep. 17: 647.
