| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| Target |
Compound Overview
ATM Inhibitor-8 is a research-grade small molecule supplied by TargetMol.
Physical Properties
| Molecular Formula | C26H34N6O2 |
|---|---|
| Molecular Weight | 462.59 g/mol |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active inhibitor of ATM, exhibiting anti-tumor activity (1), characterized by an IC50 value of 1.15 nM.
Target(s): ATM/ATR
Signaling pathway(s): PI3K/Akt/mTOR signaling, DNA Damage/DNA Repair
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
It is not recommended to store DMSO stock solutions at room temperature. Once the stock solution is prepared, aliquot into single-use volumes and store at −20 °C (or −80 °C for sensitive compounds). Room-temperature storage accelerates chemical degradation and moisture uptake. When ready to use, thaw an aliquot at room temperature, use immediately, and avoid repeated freeze-thaw cycles.
Product quality is assured — all TargetMol compounds undergo structural confirmation by ¹H NMR and purity determination by HPLC before release. If no effect is observed, consider the following: (1) the IC50 in literature may have been determined in a different cell line or assay format; (2) solubility or cell permeability may be limiting at the tested concentration; (3) establish a concentration gradient (e.g., 0.1–30 µM) tailored to your specific experimental system. A positive control compound with a known cellular effect in your assay is recommended.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
