Auranofin

Auranofin is a gold-containing compound originally developed as an anti-arthritic drug. It inhibits leukocyte activation and the release of inflammatory mediators from immune cells. In neurodegenerative disease research, Auranofin is used to study oxidative stress and neuroinflammation by targeting enzymes such as thioredoxin reductase (TrxR) and IκB kinase (IKK). Its ability to modulate redox signaling and immune responses makes it a promising candidate for therapeutic intervention in Alzheimer’s and Parkinson’s disease.

Classification: Acute toxicity, Oral (Category 3), H301

Reproductive toxicity (Category 2), H361

Safety Phrases:

• S22 - Do not breathe dust.
• S24/25 - Avoid contact with skin and eyes.
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:

• H301 Toxic if swallowed.
• H361 Suspected of damaging fertility or the unborn child.

Precautionary statements:

• P201 Obtain special instructions before use.
• P202 Do not handle until all safety precautions have been read and understood.
• P264 Wash skin thoroughly after handling.
• P270 Do not eat, drink or smoke when using this product.
• P281 Use personal protective equipment as required.
• P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
• P308 + P313 IF exposed or concerned: Get medical advice/ attention.
• P321 Specific treatment (see supplemental first aid instructions on this label).
• P330 Rinse mouth.
• P405 Store locked up.
• P501 Dispose of contents/ container to an approved waste disposal plant.

Auranofin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-493)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

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Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).