| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | AZ 31 |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
AZ31 (CAS 2088113-98-6) is a research-grade small molecule supplied by TargetMol.
Alternative names: AZ 31
Physical Properties
| CAS Number | 2088113-98-6 |
|---|---|
| Molecular Formula | C24H28N4O3 |
| Molecular Weight | 420.50 g/mol |
| SMILES | N((CH)(C)C1CCOCC1)C=2C3=C(N=CC2C(N)=O)C=CC(=C3)C=4C=CC(COC)=NC4 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM, respectively.AZ31 exhibits excellent ATR selectivity, PIKK family selectivity, and pan-kinase selectivity.AZ31 is a potent in vitro radiosensitizer that can be used for cancer research.
Target(s): ATM/ATR
Signaling pathway(s): DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
sonication can accelerate dissolution. If the compound is not dissolving, sonication is recommended. If you don't have an ultrasound machine, a lower solvent concentration or using less powder are recommended.
The concentration of stock solution should be lower than the solubility provided on the official website. Within this range, the concentration of stock solution should be set based on that of working solution. For cell experiments, it is recommended to set the stock solution concentration at least 1000 times higher than that of working solution.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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