| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | AZD 8542 |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
AZD8542 (CAS 1126366-36-6) is a research-grade small molecule supplied by TargetMol.
Alternative names: AZD 8542
Physical Properties
| CAS Number | 1126366-36-6 |
|---|---|
| Molecular Formula | C25H24N4O2 |
| Molecular Weight | 412.48 g/mol |
| SMILES | O=C(NC1=CC(C=2N=CN(C2)C)=C(C=C1C)C)C3=CC=C(OCC4=NC=CC=C4)C=C3 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
AZD8542 is an antagonist of Smoothened (SMO) and a Hedgehog (Hh) pathway antagonist with anticancer and antiproliferative activity that inhibits the growth of tumors in living organisms, and is used in the study of prostate and colon cancer.
Target(s): Hedgehog/Smoothened, Smo
Signaling pathway(s): Stem Cells, GPCR/G Protein
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Melted ice packs are generally not a concern for solid powder compounds, as the short transit period at ambient temperature does not typically affect compound integrity or potency. Powder form is inherently more stable than solution form during temperature fluctuations. Upon receipt, transfer the compound to −20 °C immediately. If you observe color change, odor, or physical changes, contact BioHippo for quality investigation.
Stock concentration (mM) = [mass (mg) × 1000] / [MW (g/mol) × volume (mL)]. Example: to prepare 10 mM stock from 5 mg of a 500 g/mol compound: volume = (5 × 1000) / (500 × 10) = 1 mL DMSO. For working solutions, dilute the DMSO stock into assay buffer: C₁V₁ = C₂V₂. For a 1 µM working solution from a 10 mM stock in a 1 mL assay volume, add 0.1 µL of stock (or pre-dilute to an intermediate concentration first).
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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